[Federal Register: December 31, 2002 (Volume 67, Number 251)]
[Notices]
[Page 79914-79918]
From the Federal Register Online via GPO Access [wais.access.gpo.gov]
[DOCID:fr31de02-56]
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ENVIRONMENTAL PROTECTION AGENCY
[OPP-2002-0343; FRL-7284-7]
Prosulfuron; Notice of Filing Pesticide Petitions to Establish
Tolerances for a Certain Pesticide Chemical in or on Food
AGENCY: Environmental Protection Agency (EPA).
ACTION: Notice.
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SUMMARY: This notice announces the initial filing of pesticide
petitions proposing the establishment of regulations for residues of
prosulfuron in or on various food commodities.
DATES: Comments, identified by docket ID number OPP-2002-0343, must be
received on or before January 30, 2003.
ADDRESSES: Comments may be submitted electronically, by mail, or
through hand delivery/courier. Follow the detailed instructions as
provided in Unit I. of the SUPPLEMENTARY INFORMATION.
FOR FURTHER INFORMATION CONTACT: Jim Tompkins, Registration Division
(7505C), Office of Pesticide Programs, Environmental Protection Agency,
1200 Pennsylvania Ave., NW., Washington, DC 20460-0001; telephone
number: (703) 305-5697; e-mail address: tompkins.jim@epa.gov.
SUPPLEMENTARY INFORMATION:
I. General Information
A. Does this Action Apply to Me?
You may be affected by this action if you are an agricultural
producer, food manufacturer, or pesticide manufacturer. Potentially
affected categories and entities may include, but are not limited to:
[sbull] Crop production (NAICS code 111)
[sbull] Animal production (NAICS code 112)
[sbull] Food manufacturing (NAICS code 311)
[sbull] Pesticide manufacturing (NAICS code 32532)
This listing is not intended to be exhaustive, but rather provides
a guide for readers regarding entities likely to be affected by this
action. Other types of entities not listed in this unit could also be
affected. The North American Industrial Classification System (NAICS)
codes have been provided to assist you and others in determining
whether this action might apply to certain entities. If you have
questions regarding the applicability of this action to a particular
entity, consult the person listed under FOR FURTHER INFORMATION
CONTACT.
B. How Can I Get Copies of this Document and Other Related Information?
1. Docket. EPA has established an official public docket for this
action under docket identification (ID) number OPP-2002-0343. The
official public docket consists of the documents specifically
referenced in this action, any public comments received, and other
information related to this action. Although a part of the official
docket, the public docket does not include Confidential Business
Information (CBI) or other information whose disclosure is restricted
by statute. The official public docket is the collection of materials
that is available for public viewing at the Public Information and
Records Integrity Branch (PIRIB), Rm. 119, Crystal Mall 2,
1921 Jefferson Davis Hwy., Arlington, VA. This docket facility is open
from 8:30 a.m. to 4 p.m., Monday through Friday, excluding legal
holidays. The docket telephone number is (703) 305-5805.
2. Electronic access. You may access this Federal Register document
electronically through the EPA Internet under the ``Federal Register''
listings at http://www.epa.gov/fedrgstr/.
An electronic version of the public docket is available through
EPA's
[[Page 79915]]
electronic public docket and comment system, EPA Dockets. You may use
EPA Dockets at http://www.epa.gov/edocket/ to submit or view public
comments, access the index listing of the contents of the official
public docket, and to access those documents in the public docket that
are available electronically. Although not all docket materials may be
available electronically, you may still access any of the publicly
available docket materials through the docket facility identified in
Unit I.B.1. Once in the system, select ``search,'' then key in the
appropriate docket ID number.
Certain types of information will not be placed in the EPA Dockets.
Information claimed as CBI and other information whose disclosure is
restricted by statute, which is not included in the official public
docket, will not be available for public viewing in EPA's electronic
public docket. EPA's policy is that copyrighted material will not be
placed in EPA's electronic public docket but will be available only in
printed, paper form in the official public docket. To the extent
feasible, publicly available docket materials will be made available in
EPA's electronic public docket. When a document is selected from the
index list in EPA Dockets, the system will identify whether the
document is available for viewing in EPA's electronic public docket.
Although not all docket materials may be available electronically, you
may still access any of the publicly available docket materials through
the docket facility identified in Unit I.B. EPA intends to work towards
providing electronic access to all of the publicly available docket
materials through EPA's electronic public docket.
For public commenters, it is important to note that EPA's policy is
that public comments, whether submitted electronically or in paper,
will be made available for public viewing in EPA's electronic public
docket as EPA receives them and without change, unless the comment
contains copyrighted material, CBI, or other information whose
disclosure is restricted by statute. When EPA identifies a comment
containing copyrighted material, EPA will provide a reference to that
material in the version of the comment that is placed in EPA's
electronic public docket. The entire printed comment, including the
copyrighted material, will be available in the public docket.
Public comments submitted on computer disks that are mailed or
delivered to the docket will be transferred to EPA's electronic public
docket. Public comments that are mailed or delivered to the docket will
be scanned and placed in EPA's electronic public docket. Where
practical, physical objects will be photographed, and the photograph
will be placed in EPA's electronic public docket along with a brief
description written by the docket staff.
C. How and To Whom Do I Submit Comments?
You may submit comments electronically, by mail, or through hand
delivery/courier. To ensure proper receipt by EPA, identify the
appropriate docket ID number in the subject line on the first page of
your comment. Please ensure that your comments are submitted within the
specified comment period. Comments received after the close of the
comment period will be marked ``late.'' EPA is not required to consider
these late comments. If you wish to submit CBI or information that is
otherwise protected by statute, please follow the instructions in Unit
I.D. Do not use EPA Dockets or e-mail to submit CBI or information
protected by statute.
1. Electronically. If you submit an electronic comment as
prescribed in this unit, EPA recommends that you include your name,
mailing address, and an e-mail address or other contact information in
the body of your comment. Also include this contact information on the
outside of any disk or CD ROM you submit, and in any cover letter
accompanying the disk or CD ROM. This ensures that you can be
identified as the submitter of the comment and allows EPA to contact
you in case EPA cannot read your comment due to technical difficulties
or needs further information on the substance of your comment. EPA's
policy is that EPA will not edit your comment, and any identifying or
contact information provided in the body of a comment will be included
as part of the comment that is placed in the official public docket,
and made available in EPA's electronic public docket. If EPA cannot
read your comment due to technical difficulties and cannot contact you
for clarification, EPA may not be able to consider your comment.
i. EPA Dockets. Your use of EPA's electronic public docket to
submit comments to EPA electronically is EPA's preferred method for
receiving comments. Go directly to EPA Dockets at http://www.epa.gov/edocket
, and follow the online instructions for submitting comments.
Once in the system, select ``search,'' and then key in docket ID number
OPP-2002-0343. The system is an ``anonymous access'' system, which
means EPA will not know your identity, e-mail address, or other contact
information unless you provide it in the body of your comment.
ii. E-mail. Comments may be sent by e-mail to opp-docket@epa.gov,
Attention: Docket ID Number OPP-2002-0343. In contrast to EPA's
electronic public docket, EPA's e-mail system is not an ``anonymous
access'' system. If you send an e-mail comment directly to the docket
without going through EPA's electronic public docket, EPA's e-mail
system automatically captures your e-mail address. E-mail addresses
that are automatically captured by EPA's e-mail system are included as
part of the comment that is placed in the official public docket, and
made available in EPA's electronic public docket.
iii. Disk or CD ROM. You may submit comments on a disk or CD ROM
that you mail to the mailing address identified in Unit I.C.2. These
electronic submissions will be accepted in WordPerfect or ASCII file
format. Avoid the use of special characters and any form of encryption.
2. By mail. Send your comments to: Public Information and Records
Integrity Branch (PIRIB) (7502C), Office of Pesticide Programs (OPP),
Environmental Protection Agency, 1200 Pennsylvania Ave., NW.,
Washington, DC 20460-0001, Attention: Docket ID Number OPP-2002-0343.
3. By hand delivery or courier. Deliver your comments to: Public
Information and Records Integrity Branch (PIRIB), Office of Pesticide
Programs (OPP), Environmental Protection Agency, Rm. 119, Crystal Mall
2, 1921 Jefferson Davis Hwy., Arlington, VA, Attention: Docket
ID Number OPP-2002-0343. Such deliveries are only accepted during the
docket's normal hours of operation as identified in Unit I.B.1.
D. How Should I Submit CBI To the Agency?
Do not submit information that you consider to be CBI
electronically through EPA's electronic public docket or by e-mail. You
may claim information that you submit to EPA as CBI by marking any part
or all of that information as CBI (if you submit CBI on disk or CD ROM,
mark the outside of the disk or CD ROM as CBI and then identify
electronically within the disk or CD ROM the specific information that
is CBI). Information so marked will not be disclosed except in
accordance with procedures set forth in 40 CFR part 2.
In addition to one complete version of the comment that includes
any information claimed as CBI, a copy of the comment that does not
contain the information claimed as CBI must be submitted for inclusion
in the public
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docket and EPA's electronic public docket. If you submit the copy that
does not contain CBI on disk or CD ROM, mark the outside of the disk or
CD ROM clearly that it does not contain CBI. Information not marked as
CBI will be included in the public docket and EPA's electronic public
docket without prior notice. If you have any questions about CBI or the
procedures for claiming CBI, please consult the person listed under FOR
FURTHER INFORMATION CONTACT.
E. What Should I Consider as I Prepare My Comments for EPA?
You may find the following suggestions helpful for preparing your
comments:
1. Explain your views as clearly as possible.
2. Describe any assumptions that you used.
3. Provide copies of any technical information and/or data you used
that support your views.
4. If you estimate potential burden or costs, explain how you
arrived at the estimate that you provide.
5. Provide specific examples to illustrate your concerns.
6. Make sure to submit your comments by the deadline in this
notice.
7. To ensure proper receipt by EPA, be sure to identify the docket
ID number assigned to this action in the subject line on the first page
of your response. You may also provide the name, date, and Federal
Register citation.
II. What Action is the Agency Taking?
EPA has received a pesticide petition as follows proposing the
establishment and/or amendment of regulations for residues of a certain
pesticide chemical in or on various food commodities under section 408
of the Federal Food, Drug, and Cosmetic Act (FFDCA), 21 U.S.C. 346a.
EPA has determined that this petition contains data or information
regarding the elements set forth in FFDCA section 408(d)(2); however,
EPA has not fully evaluated the sufficiency of the submitted data at
this time or whether the data support granting of the petition.
Additional data may be needed before EPA rules on the petition.
List of Subjects
Environmental protection, Agricultural commodities, Feed additives,
Food additives, Pesticides and pests, Reporting and recordkeeping
requirements.
Dated: December 20, 2002.
Debra Edwards,
Acting Director, Registration Division, Office of Pesticide Programs.
Summary of Petitions
The petitioner's summary of the pesticide petitions is printed
below as required by FFDCA section 408(d)(3). The summary of the
petitions was prepared by the petitioner and represents the view of the
petitioner. The petitions summary announces the availability of a
description of the analytical methods available to EPA for the
detection and measurement of the pesticide chemical residues or an
explanation of why no such method is needed.
EPA has received pesticide petitions (PP 5F4469) and (PP 4F4336),
from Syngenta Crop Protection, Inc., P.O. Box 18300, Greensboro, NC
27419-8300 proposing, pursuant to section 408(d) of the Federal Food,
Drug, and Cosmetic Act (FFDCA), 21 U.S.C. 346a(d), to amend 40 CFR part
180 by establishing a tolerance for residues of prosulfuron, 1-(4-
methoxy-6-methyl-triazin-2-yl)-3-[2-(3,3,3-trifluoropropyl)-
phenylsulfonyl]-urea in or on the raw agricultural commodities, cereal
grains group (except rice and wild rice) grain at 0.01 parts per
million (ppm), cereal grains group (except rice and wild rice) forage
at 0.10 ppm, cereal grains group (except rice and wild rice) fodder at
0.01 ppm, cereal grains group (except rice and wild rice) straw at 0.02
ppm, cereal grains group (except rice and wild rice) hay at 0.20 ppm,
milk at 0.01 ppm, meat, fat, kidney, liver, and meat by-products of
cattle, goats, hogs, horses, and sheep at 0.05 ppm. EPA has determined
that the petition contains data or information regarding the elements
set forth in section 408(d)(2) of the FFDCA; however, EPA has not fully
evaluated the sufficiency of the submitted data at this time or whether
the data support granting of the petition. Additional data may be
needed before EPA rules on the petition.
This is a revised notice of filing to amend a previous notice of
filing published in the Federal Register of August 25, 1999 (FR 64
46382) (FRL-6093-7), to propose permanent tolerances, instead of the
current time-limited tolerances for prosulfuron.
A. Residue Chemistry
1. Plant metabolism. The nature of the residue of prosulfuron in
corn is adequately understood. Significant pathways involve oxidation
of the phenyl ring to give 5-hydroxy prosulfuron, which is followed by
sugar conjugation. Hydrolytic cleavage of the sulfonylurea bridge
occurs for both prosulfuron and 5-hydroxy prosulfuron, yielding the
corresponding sulfonamide and triazine amine moieties. The sulfonamide
metabolites are subsequently conjugated with sugars. Demethylation of
the triazine amine results in the formation of the corresponding
hydroxy triazine, which is further hydrolyzed at the amino group to
form the dihydroxy triazine.
2. Analytical method. Adequate analytical methods exist for the
detection and measurement of residue levels of prosulfuron in or on raw
and processed commodities of cereal grains, and for meat, milk and
eggs. The limit of quantitation (LOQ) is 0.01 ppm for crop commodities,
processed fractions and milk, and 0.05 ppm for meat and eggs. The
method is based on commodity-specific cleanup procedures followed by
determination by high performance liquid chromatography with
ultraviolet (UV) detection.
3. Magnitude of residues. Complete, full geography residue
programs, including processing, have been conducted on corn, wheat and
grain sorghum. A three-level dairy animal feeding study to determine
the transfer of residues of prosulfuron from animal feed commodities to
meat and milk has also been conducted.
B. Toxicological Profile
1. Acute toxicity. EPA has set an acute reference dose of 0.1
milligram/kilogram/day (mg/kg/day) based upon a no observed adverse
effect level (NOAEL) of 10 mg/kg/day from the rat acute neurotoxicity
study (lowest observed adverse effect level (LOAEL) of 250 mg/kg/day
due to reduced motor activity and body temperature in males and
impaired righting reflex in females) and a 100-fold uncertainty factor
(UF).
2. Genotoxicty. Prosulfuron was negative for mutagenic/genotoxic
effects when tested in a bacterial reverse gene mutation assay with and
without metabolic activation using different S. typhimurium and E. coli
stains; in a mammalian gene mutation study using V79 cells; in an in
vitro mammalian cytogenetic test using Chinese hamster ovary (CHO)
cells with and without metabolic activation; in a micronucleus test in
mice; and in a DNA- repair using freshly isolated rat liver
hepatocytes.
3. Reproductive and developmental toxicity. The data base on
prosulfuron relative to prenatal and postnatal effects for children is
considered to be essentially complete with no data gaps. The
developmental and reproductive toxicity data do not indicate increase
susceptibility of rats or rabbits to in utero and/or postnatal exposure
to
[[Page 79917]]
prosulfuron. In a rat teratology study, evidence of maternal toxicity
(decreased body weight gain and reduced food consumption) and
developmental toxicity (increased incidence of skeletal variations that
was not significantly different from the historical control) was found
at the maximum tolerated dose of 400 mg/kg. There was no evidence of
teratogenicity at any dose, and the maternal and developmental NOAELs
were established at 200 mg/kg. In a rabbit teratology study, maternal
toxicity (decreased body weight gain and reduced food consumption) was
observed in the 100 mg/kg dose group. There was no evidence of
teratogenicity at any dose. Since a range-finding rabbit teratology
study had seen additional clinical findings and fetotoxicity at
maternally toxic doses (>=150 mg/kg) but not in the definitive study at
up to 100 mg/kg, a second rabbit teratology study was conducted at
doses of 0, 20, 100, and 200 mg/kg/day. Maternal toxicity was observed
at 200 mg/kg. The developmental NOAEL was 100 mg/kg and the maternal
NOAEL was 20 mg/kg in this study. There was no evidence of
teratogenicity at any dose. A rat multigenerational reproduction study
indicated reproductive and systemic NOAELs of 13.3 mg/kg/day based on
decreased mean body weights and body weight gain observed at 136 mg/kg/
day for both pups and parental animals. No treatment-related effects on
reproductive performance (i.e., to produce, deliver or raise litters),
litter sizes, viability of pups, and necropsy findings in parental
animals and offspring were noted up to the highest dose level.
4. Subchronic toxicity. The liver was identified as a target organ
at high doses in the rat, mouse, and dog as indicated by slightly
increased liver enzymes and liver weights. No histomorphologic
correlates of liver damage was noted in the 90-day studies except in
the mouse study where centrilobular hypertrophy was found in males at
feeding levels >=1,750 ppm and in females at levels >=3,500 ppm. In
general, NOAELs for target organ effects were established at doses that
were much higher than overall study NOAELs, which were based on other
indicators of toxicity such body weight gain.
5. Chronic toxicity. In the 1-year dog chronic dosing study, the
NOAEL was 1.84 mg/kg/day based on hematologic and clinical chemistry
effects and incidence of lipofuscin accumulation in the liver at 18.6
mg/kg/day. In the 18-month mouse carcinogenicity study, there was no
evidence of carcinogenic effects up to the highest dose tested (HDT) of
1,062 mg/kg/day. The NOAEL was 1.71 mg/kg/day in males, and 100 mg/kg/
day in females based on increased incidence/severity of centrilobular
hepatocellular hypertrophy. A 2-year chronic feeding/carcinogenicity
study in rats indicated systemic NOAEL of 7.9 mg/kg/day was based on
decreased body weight and body weight gain, hematopoietic effects
(males), and possibly increased serum GGT and decreased liver, kidney,
and adrenal weights (females) at 79.9 mg/kg/ day. There was uncertain
evidence of carcinogenicity with slight increases in the incidence of
mammary gland adenocarcinomas in females at 95.7 and 205.8 mg/kg/day,
slight increase in incidence of benign testicular interstitial cell
tumors at 79.9 and 160.9 mg/kg/day (significant trend only).
Considering the weight of the evidence, the EPA Reference Dose
Committee previously concluded that the chemical should be classified
as a Group D carcinogen (inadequate evidence), not classifiable as to
human carcinogenicity. The HIARC (meeting December 2, 1999) accepted
the previous conclusions and updated the cancer classification to the
new classification: ``data are inadeqate,'' with no new studies
required. EPA has set a chronic reference dose of 0.02 mg/kg based on a
NOAEL of 1.84 mg/kg in a dog feeding study and a 100-fold UF.
6. Animal metabolism. The metabolic pathways in the rat, goat, and
hen are similar and are adequately understood. Prosulfuron is rapidly
absorbed from the gastrointestinal (GI) tract of rats and is rapidly
excreted. Approximately 90% of the administered dose is excreted during
the first 48 hours, predominately via urine. Tissue residues are low.
Prosulfuron is metabolized primarily via hydroxylation at side chain
and phenyl ring positions and O-demethylation of the triazyl methoxy
group. Minor pathways include unsaturation of the trifluoropropyl side
chain, hydrolysis of the phenylsulfonylurea bridge and oxidative/
hydrolytic cleavage of the triazine ring system. In the goat, the
orally administered prosulfuron is quickly eliminated primarily via the
urine as prosulfuron. The metabolism of prosulfuron in the goat follows
a similar pathway as observed in the rat although not as extensive. The
majority of the residues were accounted for as prosulfuron, the
triazine amine, which results from bridge hydrolysis (CGA-150829) and
the triazinyl hydroxymethyl metabolite (CGA-273437). In the hen,
metabolism is similar to that observed in the rat and goat. The major
residues found in edible tissues and eggs were prosulfuron, the
triazine amine (CGA-150829), and the sulfonamide (CGA-159902) which
results from hydrolysis of the sulfonylurea bridge.
7. Metabolite toxicology. Metabolic pathways of prosulfuron in
plants and animals are comparable and no detectable residues are found
in or on crops. All relevant plant metabolites are observed in the
animals and are thus toxicologically covered. The remaining plant
metabolites are toxicologically insignificant. Therefore, parent
prosulfuron is the appropriate compound for the tolerance expression
and analytical monitoring.
8. Endocrine disruption. Prosulfuron does not belong to a class of
chemicals known for having significant adverse effects on the endocrine
system. Developmental toxicity studies in rats and rabbits and
reproduction study in rats gave no indication that prosulfuron might
have any effects on endocrine function related to development and
reproduction. The subchronic and chronic studies also showed no
evidence of a long-term effect related to the endocrine system.
C. Aggregate Exposure
1. Dietary exposure. Acute and chronic dietary exposure assessments
were conducted for prosulfuron using tolerance values published in 40
CFR 180.481. In both assessments it was assumed that 100% of all corn
and cereal grains were treated with prosulfuron (100% market share).
The exposure analyses was conducted using food consumption data from
USDA's 1994-1996 Continuing Survey of Intake by Individuals (CSFII) and
Novigen Sciences, Inc. Dietary Exposure Evaluation Model (DEEM).
i. Food. Chronic exposure was compared to a RfD of 0.02 mg/kg based
on a NOAEL of 1.84 mg/kg in a dog feeding study and a 100-fold UF. This
exposure analysis showed that the U.S. population had an exposure of
less than 1% of the chronic RfD. The most sensitive subpopulation was
children (1-6 years old) with a chronic exposure of 2.4%. Acute
exposure was compared to an acute RfD of 0.1 mg/kg, which was based on
a NOAEL of 10 mg/kg from an acute neurotoxicity study in the rat and a
100-fold UF. The most sensitive subpopulation was all infants with an
exposure of 2.2% of the acute RfD. The U.S. population showed an
exposure of 1.5% of the RfD. These results show that there is more than
a reasonable certainty of no harm, through exposure to prosulfuron
residues in the diet.
ii. Drinking water. For estimated surface water concentrations
using generic expected environmental concentration (GENEEC), the peak
day-
[[Page 79918]]
0 estimate, 1.86 parts per billion (ppb), was used in the acute
exposure analysis and the corrected 56-day drinking water concentration
of 0.4667 ppb was used in the chronic exposure analysis. The SCI-GROW
estimated ground water concentration for the prosulfuron uses of
0.406585 ppb contributed little to the overall exposure. The acute
drinking water levels of concern (DWLOC) for prosulfuron were based on
the acute RfD, a margin of exposure (MOE), the 99.9th
percentile of the acute dietary exposure for U.S. population subgroups
and the body weight - daily water consumption of each respective
subgroup. The calculated acute DWLOC values for the population
subgroups ranged from 978-3447 ppb. The estimated ground water
concentration (0.406585 ppb) and the peak day-0 surface water
concentration (1.86 ppb) of prosulfuron did not exceed the acute DWLOC
values. The chronic (non-cancer) DWLOC for prosulfuron were based on
the chronic RfD, any estimated residential exposure, the chronic
dietary exposure for select U.S. population subgroups and the body
weight - daily water consumption of each respective subgroup. The
calculated chronic DWLOC values for the population subgroups ranged
from 197-694. The estimated ground water concentration (0.406585 ppb)
and the corrected average 56-day surface water concentration (0.4667
ppb) of prosulfuron did not exceed the chronic DWLOC values. Therefore,
there is reasonable certainty that the residues of prosulfuron in the
drinking water would not result in unacceptable levels of acute or
chronic aggregate human health risk, and that such exposure would not
exceed the exposure allowable by the risk cup.
Nondietary exposure. Nondietary exposure to prosulfuron is
considered negligible as the chemical is registered for agricultural
use only. For workers handling this chemical, acceptable MOE (in the
range of thousands) have been obtained for both acute and chronic
scenarios.
D. Cumulative Effects
Consideration of a common mechanism of toxicity is not appropriate
at this time since there is no information to indicate that toxic
effects produced by prosulfuron would be cumulative with those of any
other types of chemicals.
E. Safety Determination
1. U.S. population. The calculation shows that less than 1% of the
RfD will be utilized for the U.S. population based on chronic toxicity
endpoints. EPA generally has no concern for exposures below 100% of the
RfD because the RfD represents the level at or below which daily
aggregate dietary exposure over a lifetime will not pose appreciable
risks to human health. It is concluded that there is a reasonable
certainty that no harm will result from aggregate exposure to
prosulfuron residue.
2. Infants and children. The calculated percent of the RfD that
will be utilized by aggregate exposure to residues of prosulfuron is
only 2.4% for children (1 to 6 years old), the most impacted
subpopulation. There were no adverse reproductive or developmental
effects indicated in the prosulfuron toxicity data base, which is
considered to be essentially complete with no data gaps. It is
concluded that there is a reasonable certainty that no harm will result
to infants and children from aggregate exposure to prosulfuron
residues.
F. International Tolerances
No codex MRLs have been established for residues of prosulfuron.
[FR Doc. 02-32988 Filed 12-30-02; 8:45 am]
BILLING CODE 6560-50-S