[Federal Register: February 7, 2003 (Volume 68, Number 26)]
[Notices]               
[Page 6483-6488]
From the Federal Register Online via GPO Access [wais.access.gpo.gov]
[DOCID:fr07fe03-78]                         


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DEPARTMENT OF HEALTH AND HUMAN SERVICES


Centers for Disease Control and Prevention


[Program Announcement 03027]


 
Grants for New Investigator Training Awards for Unintentional 
Injury, Violence Related Injury, Acute Care, Disability, and 
Rehabilitation-Related Research


    Application Deadline: April 8, 2003.


A. Authority and Catalog of Federal Domestic Assistance Number


    This program is authorized under section 301 (a) (42 U.S.C. 241(a)) 
of the Public Health Service Act, and section 391 (a) (42 U.S.C. 280b 
(a)) of the Public Service Health Act, as amended. The catalog of 
Federal Domestic Assistance number is 93.136.


B. Purpose


    The Centers for Disease Control and Prevention (CDC) announces the 
availability of fiscal year (FY) 2003 funds for grants for new 
investigator training awards in four research areas: unintentional 
injury prevention, violence-related injury prevention, injury-related 
acute care and disability research, and injury-related biomechanics 
research. This program addresses the ``Healthy People 2010'' focus 
areas of Injury and Violence Prevention.
    The purposes of this program are to:
    1. Solicit research applications that address the priorities 
reflected under the ``Program Requirements'' section.
    2. Encourage professionals from a wide spectrum of disciplines of 
engineering, epidemiology, medicine, biostatistics, public health, law 
and criminal justice, and behavioral, and social sciences to perform 
research in order to prevent and control injuries more effectively.
    3. Support injury research by recent doctoral-level graduates or 
researchers who are redirecting their careers toward injury research.
    4. Build the scientific base for the prevention and control of 
unintentional and violence-related injuries, disabilities, and deaths.
    5. Encourage qualified applicants who are beginning or redirecting 
their career to focus on injury-related research. The career 
development objectives of this program are to encourage scientists to 
develop independent research skills and to gain experience in advanced 
methods and experimental approaches in injury-related research. This 
program is also intended to jump start the careers of researchers in 
injury prevention and control by providing support for pilot studies, 
enhancements to existing studies, or other studies that will serve as a 
foundation for a career in injury prevention and control. Applicants 
are required to seek mentoring or collaboration for their research with 
more senior-level injury researchers.
    Measurable outcomes of the program will be in alignment with the 
performance goal for the National Center for Injury Prevention and 
Control (NCIPC): Develop new or improved approaches for preventing and 
controlling death and disability due to injuries.


Background and Significance


1. Unintentional Injury Prevention Research
    For the purposes of this RFA, unintentional injuries are defined as 
unintentional damage to the body resulting from acute exposure to 
thermal, mechanical, electrical, or chemical energy or from the absence 
of such essentials as heat or oxygen. Unintentional injuries continue 
to be a major public health problem. In 1999, nearly 98,000 people died 
in the United States as a result of unintentional injuries. Someone 
dies in this country every six minutes from an injury that is within a 
category of injuries that includes: motor vehicle crashes, falls, 
poisonings, drowning, fires and burns, pedestrians struck by motor 
vehicles, bicycle crashes, or suffocation. In addition to deaths, 
injuries also constitute a significant cause of both permanent and 
temporary disability. In 2000, unintentional injuries resulted in 
nearly 30 million emergency department visits and millions more visits 
to physicians' offices. Although the greatest cost of injury is human 
pain and suffering, the financial costs also are staggering: over 200 
billion dollars annually for medical care, wage and productivity losses 
and employer costs in 1998.


[[Page 6484]]


2. Violence Related Injury Prevention Research
    Deaths and injuries associated with interpersonal violence and 
suicidal behavior are also a major public health problem in the U.S. 
and around the world. In 1999, over 46,000 people died from homicide 
and suicide in the U.S. Among 15 to 24 year olds, homicide and suicide 
ranked as the second and the third leading causes of death. Violent 
deaths are the most visible consequence of violent behavior in our 
society. Morbidity associated with physical and emotional injuries and 
disabilities resulting from violence, however, also constitute an 
enormous public health problem. For every homicide that occurs each 
year there are over 100 nonfatal injuries resulting from interpersonal 
violence. For every completed suicide it is estimated that there are 20 
to 25 suicide attempts. The mortality and morbidity resulting from 
violence are associated with a variety of types of violence including 
child maltreatment, youth violence, intimate partner violence, sexual 
violence, elder abuse, and self-directed violence or suicidal behavior.


3. Injury Related Acute Care, Disability, and Rehabilitation


    Each year, Americans make between 30 and 40 million emergency 
department (ED) visits for injuries. While most injured patients are 
treated and released, many are admitted to inpatient trauma units and 
later receive rehabilitative services. The most favorable outcomes are 
achieved when acute care and subsequent rehabilitation are as early as 
possible and focus on returning patients to baseline or to an optimal 
level of functioning. Trauma systems are designed to match trauma 
patients with the acute care and rehabilitative facilities they need, 
but in many parts of the U.S. trauma systems are not fully operational 
or are nonexistent. Also, as many as 30 to 40 percent of deaths among 
trauma patients are due to preventable problems in clinical care, 
including missed diagnoses and treatment delays.
    Injuries are a major cause of disabilities in the U.S. Central 
nervous system injuries (those to the brain and spinal cord) are most 
likely to result in serious long-term disability. Each year, an 
estimated 80,000 Americans sustain a traumatic brain injury (TBI) that 
results in disability; an estimated 5.3 million Americans live with 
TBI-related disability. Although physical impairments from the injury 
may contribute to TBI disability, cognitive deficits are the hallmark, 
frequently resulting in secondary conditions such as depression and 
other adverse outcomes such as the inability to work. An estimated 
177,000 to 200,000 people in the U.S. live with spinal cord injuries 
(SCI), and this number increases annually by as many as 20,000 
individuals.


4. Biomechanics


    The field of biomechanics quantifies the response and tolerance of 
the human body to impact (e.g., motor vehicle collisions, playground 
falls, and child battering) and addresses the underlying mechanisms of 
injury, the forces deforming the body and the physiologic effects of 
injury to infants, children, adults and the aged population. Based on 
interdisciplinary research, the engineering factors are determined that 
deform the body and the medical consequences are quantified that affect 
vital functions. This knowledge is used to modify the design of 
protective systems to improve safety. Improved safety systems protect 
an individual from impact forces that can injure, and they can include 
protective equipment (cycling helmets) and environments (playground 
surfaces), occupant restraints (airbags and safety belts), and policies 
(rules to minimize spearing in football). Biomechanical knowledge can 
also be used to improve post-injury outcomes through physiologic models 
to address emergency medical treatments, pharmacologic interventions 
and rehabilitation to advance recovery.
    An overview of the role of biomechanics in a national effort for 
injury control was included in the landmark NAS study ``Injury in 
America: A Continuing Public Health Problem-Committee on Trauma 
Research'' (Commission on Life Sciences, National Research Council and 
the Institute of Medicine, National Academy Press, Washington, DC, 
1985). The role is described in more detail in a follow-on paper from 
the NAS study: Injury Biomechanics Research: An Essential Element in 
the Prevention of Trauma (Viano DC, King AI, Melvin JW, Weber K. 
Journal of Biomechanics, 22(5): 403-417, 1989).
    This program attempts to build on the basic knowledge of 
biomechanics and encourage interdisciplinary intervention-oriented 
injury control research as supported in the ``CDC Injury Research 
Agenda'' (See Attachment 2 as posted on the CDC Web site).


C. Eligible Applicants


    Applications may be submitted by public and private nonprofit and 
for profit organizations and by governments and their agencies; that 
is, universities and colleges (including but not limited to schools or 
departments of public health, medicine, nursing, criminal justice, 
bioengineering, or the behavioral or social sciences,) technical 
schools, research institutions, hospitals, other public and private 
nonprofit and for profit organizations, community-based organizations, 
faith-based organizations, State and local governments or their bona 
fide agents, including the District of Columbia, the Commonwealth of 
Puerto Rico, the Virgin Islands, the Commonwealth of the Northern 
Mariana Islands, American Samoa, Guam, the Federated States of 
Micronesia, the Republic of the Marshall Islands, and the Republic of 
Palau, Federally recognized Indian tribal governments, Indian tribes, 
or Indian tribal organizations, and small, minority, and/or women-owned 
businesses.


    Note: Title 2 of the United States Code section 1611 states that 
an organization described in section 501(c)(4) of the Internal 
Revenue Code that engages in lobbying activities is not eligible to 
receive Federal funds constituting an award, grant or loan.


    Applicants must have a research or a health-professional doctorate-
level degree from an accredited program and have demonstrated the 
capacity or potential for highly productive research in the period 
after the doctorate, commensurate with level of experience. Applicants 
must be within three years of having completed their doctoral or 
equivalent graduate work (including dissertation, where appropriate), 
or redirecting their research to injury-related research. Documentation 
of such redirection such as letters indicating recent substantive 
involvement in injury research or injury-related publications must be 
included in the application. Applicants who have been the principal 
investigator on a Public Health Service (PHS) injury-related research 
grant or who have had equivalent injury-related research support from 
an existing Injury Control Research Center (ICRC) are not eligible. 
Exceptions are researchers who have redirected their research areas 
from one area of injury research, e.g., acute care or biomechanics, to 
another area, e.g., violence prevention research. Recipients of 
dissertation research grants or National Institutes of Health (NIH) 
Small Grant Awards are eligible to apply.
    Applications that are incomplete or non-responsive to the following 
requirements will be returned to the applicant without further 
consideration:


[[Page 6485]]


    1. A principal investigator who has specific authority and 
responsibility to carry out the proposed project.
    2. Effective and well-defined working relationships within the 
performing organization and with outside entities, which will ensure 
implementation of the proposed activities.
    3. The ability to carry out injury control research projects as 
defined under Attachment 2 (1. a-c) as posted on the CDC website.
    4. The overall match between the applicant's proposed theme and 
research objectives and the program priorities as described under the 
heading, ``Program Requirements''.
    5. Mentorship as noted in the letter of support and commitment of 
mentor's time.


D. Funding


Availability of Funds


    Approximately $400,000 is available in FY 2003 to fund 
approximately four awards. It is expected that the award will begin on 
or about September 1, 2003, and will be made for a 12-month project 
period. Grants will be awarded for 12 months, but may be extended 
without additional funds for up to a total of 24 months. The maximum 
funding level for each project will not exceed $100,000 (direct and 
indirect costs) per year. Funding estimates may change.
    Applications that exceed the funding caps noted above will be 
excluded from the competition and returned to the applicant. The 
availability of federal funding may vary and is subject to change.


    Note: Grant funds will not be made available to support the 
provision of direct care. Eligible applicants may enter into 
contracts, including consortia agreements, as necessary to meet the 
requirements of the program and strengthen the overall application.


Use of Funds


    The use of funds for applicant include, partial salary and tuition 
support; direct research project expenses, such as trainee stipends, 
interviewer costs, data processing, participant incentives, statistical 
consultation services, and supplies; and travel to one scientific 
meeting, if adequately justified. Applicants should also include travel 
costs for one, two-day trip to CDC in Atlanta to present research 
findings. Funds for tuition support are limited to no more than 20 
percent of the overall award and their use must be generally related to 
the content and methods of the proposed research. Indirect cost for 
these trainee-related activities are limited to eight percent.


Recipient Financial Participation


    Matching funds are not required for this program.


E. Program Requirements


    Applicants are encouraged to propose studies that can feasibly be 
completed within the available funds and funding period.


Research Objectives


    For the purpose of this Program Announcement, highest consideration 
will be given to research that addresses one of the following research 
areas and subtopics:


Violence


    1. Evaluation of strategies for disseminating and implementing 
evidence-based interventions or policies for the prevention of intimate 
partner violence, sexual violence (includes both sexual violence 
against adults and child sexual abuse), child maltreatment, youth 
violence or suicidal behavior.
    2. Evaluation of the efficacy, effectiveness, and cost 
effectiveness of interventions, programs, and policies to prevent 
intimate partner violence, sexual violence, child maltreatment, youth 
violence or suicidal behavior.
    3. Identification of shared and unique risk and protective factors 
for the perpetration of intimate partner violence, sexual violence, 
child maltreatment, youth violence or suicidal behavior, and examine 
the relationships among these forms of violence.


Unintentional Injury


    1. Development of strategies that encourage practitioners and 
policy makers to adopt science-based programs, policies, laws, and 
regulations that reduce unintentional injuries.
    2. Identification of modifiable behavioral responses to a 
residential fire and evaluating the effectiveness of evacuation 
strategies in fire emergencies and mass trauma events.
    3. Among children, determination of the immediate causes of the 
most severe and disabling types of falls, or evaluating interventions 
that prevent serious falls in children.
    4. Development of interventions that utilize applied behavioral 
analysis, behavioral safety, or other behavior modification strategies 
to change injury risk behaviors in non-occupational settings.
    5. Development and implementation of interventions to increase 
motor vehicle safety in older adult drivers.
    6. Evaluation of the effectiveness of implementing new innovative 
strategies to reduce alcohol-impaired driving.
    7. Evaluation of the effectiveness of environmental, engineering or 
behavioral interventions to prevent pedestrian injury.
    8. Methodological research to better define and measure aspects of 
supervision and its relative effectiveness in preventing injuries


Acute Care, Disability, and Rehabilitation


    1. Development and evaluation of protocols that provide onsite 
interventions in acute care settings or linkages to off-site services 
for patients at risk of injury or psychosocial problems following 
injury.
    2. Development and application of methods that can be used to 
calculate population-based estimates of the incidence, costs, and long-
term consequences of spinal cord injury (SCI) and nonhospitalized 
traumatic brain injury (TBI). Identification of methods and strategies 
to ensure that people with TBI and SCI receive needed services.


Biomechanics


    1. Use of biomechanics research and the knowledge of injury 
tolerance and injury mechanisms for the development and evaluation of 
interventions that address the following specific injury prevention and 
control problems:
    a. Falls among older, community dwelling adults (e.g., hip pads).
    b. Injuries in mass trauma events.
    c. Severe and disabling falls among children.
    d. Sports, recreation, and exercise related injuries (e.g., 
playground and other play environments, safety gear).
    e. Injuries associated with people initiating or increasing 
physical activity (e.g., training programs or protective devices).
    f. Injuries related to outdoor recreation (e.g., vehicle design).
    g. Motorcycling, bicycling and pedestrian injuries (e.g., vehicle 
design).
    h. Injuries to child occupants of motor vehicles (e.g., universal 
fasteners and alternative restraint designs).
    i. Injuries to older drivers.
    j. Injuries associated with the effects of emerging vehicle 
technologies.
    2. Development of more basic biomechanical information that is 
needed to identify biomechanics and specific injuries that would be 
highly predictive of diagnoses of intimate partner violence and child 
maltreatment and improve case definitions.
    3. Advancement of the biomechanical understanding of traumatic 
injury (e.g., injuries to the brain, spinal cord, thorax/


[[Page 6486]]


abdomen, extremities and joints) including the development of 
biofidelic models to elucidate injury physiology as well as 
pharmacologic, surgical, rehabilitation, and other interventions; 
improvement of injury assessment technology; impact injury mechanisms 
research; and quantification of injury-related biomechanical responses 
for critical areas of the human body (e.g., brain and vertebral injury 
with spinal cord involvement).
    4. Definition of the human tolerance limits for injury, especially 
determining the differences in human tolerance by age, fitness level, 
and gender and the biomechanics and injury tolerances of tissue, bone, 
and other human structures as a prerequisite for developing 
interventions.
    5. Identification of the modifiable risk factors for and mechanisms 
of nonfatal neck, back, and soft tissue (whiplash-like) injuries.


Other Special Conditions for New Investigator Research Grants


    1. The applicant must be the designated principal investigator. The 
principal investigator must be responsible for planning, directing, and 
executing the proposed project. The applicant must include a signed 
letter indicating that he or she personally wrote the application.
    2. The applicant must specify which of four areas the proposal 
addresses: (a) Unintentional injury; (b) violence-related injury 
research; (c) injury-related acute care, disability, and 
rehabilitation; or (d) biomechanics.
    3. The applicant must provide measures of effectiveness that will 
demonstrate the accomplishment of the various identified objectives of 
the grant. Measures must be objective/quantitative and must measure the 
intended outcome. These measures of effectiveness must be submitted 
with the application and will be an element of the application 
evaluation.
    4. The grant may not be transferred to another institution, except 
under unusual and compelling circumstances (such as if the mentor moves 
to a new institution and both the mentor and the applicant wish to move 
together).
    5. Any publications directly resulting from the grant should be 
reported to the responsible CDC program official. The grantee also must 
cite receiving support from HHS/CDC/NCIPC in any publications directly 
resulting from the new investigator grant.


F. Content


Letter of Intent (LOI)


    The LOI is optional for this program. The narrative should be no 
more than single-spaced pages, printed on one side, with one-inch 
margins, and unreduced 12-point font. Your letter should identify the 
announcement number, the name of the principal investigator, and 
briefly describe the scope and intent of the proposed research work. 
The letter of intent does not influence review or funding decisions, 
but the number of letters received will enable CDC to plan the 
application review more effectively and efficiently.


Applications


    The Program Announcement title and number must appear in the 
application. Use the information in the Program Requirements, Other 
Requirements, and Evaluation Criteria sections to develop the 
application content. Your application will be evaluated on the criteria 
listed, so it is important to follow them in laying out your program 
plan. The narrative should be no more than 25 single-spaced pages, 
printed on one side, with one-inch margins, and unreduced 12-point 
font.
    Applications should follow the PHS-398 (Rev. 5/2001) application 
and Errata sheet, and the narrative should include the following 
information:
    1. The project's focus that justifies the research needs and 
describes the scientific basis for the research, the expected outcome, 
and the relevance of the findings to reduce injury morbidity, 
mortality, disability, and economic losses. This focus should be based 
on recommendations in ``Healthy People 2010'' and the ``CDC Injury 
Research Agenda'' and should seek creative approaches that will 
contribute to a national program for injury control.
    2. Specific, measurable, and time-framed objectives.
    3. A detailed plan, which describes the methods by which the 
objectives will be achieved, including their sequence. A comprehensive 
evaluation plan is an essential component of the application.
    4. A description of the roles and responsibilities of the principal 
investigator and mentor, where appropriate.
    5. A description of all project staff regardless of their funding 
source. It should include their title, qualifications, experience, 
percentage of time each will devote to the project, as well as that 
portion of their salary to be paid by the grant.
    6. A description of those activities related to, but not supported 
by the grant.
    7. A description of the involvement of other entities that will 
relate to the proposed project, if applicable. It should include 
letters of organizational commitments of support and a clear statement 
of their roles.
    8. A detailed budget for the grant.
    9. An explanation of how the research findings will contribute to 
the national effort to reduce the morbidity, mortality and disability 
caused by injuries.
    10. An evaluation plan for the project, including quantifiable 
measures of effectiveness.


Additional Materials Required


    In addition to the completed PHS 398 application form, the 
applicant must also submit the following materials, attached to the 
application as appendices:
    1. An official transcript of the applicant's graduate school 
record, if within the last three years.
    2. When relevant, documentation showing the researcher has 
redirected his or her career within the last three years.
    3. A justification for any proposed tuition support.
    4. An overview of the applicant's prior research training and 
experience as well as a statement of the applicant's short-term and 
long-term research and career goals and intended career trajectory.
    5. A letter from the applicant's mentor or scientific collaborator 
that outlines the proposed plan for providing scientific advice and 
consultation to the applicant during the grant period and a biography 
of the mentor or senior-level collaborator, limited to two pages (Use 
the Biographical Sketch page in application form PHS 398.)


G. Submission and Deadline


Letter of Intent (LOI) Submission


    On or before March 4, 2003, submit the LOI to the Grants Management 
Specialist identified in the ``Where to Obtain Additional Information'' 
section of this announcement.


Application Forms


    Submit the original and two copies of PHS-398 (OMB Number 0925-
0001). Forms are available at the following Internet address: 
www.cdc.gov/od/pgo/forminfo.htm.
    If you do not have access to the Internet, or if you have 
difficulty accessing the forms on-line, you may contact the CDC 
Procurement and Grants Office Technical Information Management Section 
(PGO-TIM) at 770-488-2700, and forms can be mailed to you.


Submission Date, Time, and Address


    The application must be received by 4 p.m. eastern time, April 8, 
2003.


[[Page 6487]]


Submit the application to: Technical Information Management--PA 03027, 
Procurement and Grants Office, Centers for Disease Control Prevention, 
2920 Brandywine Rd, Room 3000, Atlanta, GA 30341-4146.
    Applications may not be submitted electronically.


CDC Acknowledgement of Application Receipt


    A postcard will be mailed by PGO-TIM, notifying you that CDC has 
received your application.


Deadline


    Letters of intent and applications shall be considered as meeting 
the deadline if they are received before 4 p.m. eastern time on the 
deadline date. Any applicant who sends their application by the United 
States Postal Service or commercial delivery services must ensure that 
the carrier will be able to guarantee delivery of the application by 
the closing date and time. If an application is received after closing 
due to (1) carrier error, when the carrier accepted the package with a 
guarantee for delivery by the closing date and time, or (2) significant 
weather delays or natural disasters, CDC will upon receipt of proper 
documentation, consider the application as having been received by the 
deadline.
    Any application that does not meet the above criteria will not be 
eligible for competition and will be discarded. Applicants will be 
notified of their failure to meet the submission requirements.


H. Evaluation Criteria


Application


    Upon receipt, applications will be reviewed by CDC staff for 
completeness, responsiveness, and eligibility as outlined under the 
``Eligible Applicants'' section. Incomplete applications and 
applications that are not responsive will be returned to the applicant 
without further consideration.
    It is especially important that the applicant's abstract reflects 
the project's focus, because the abstract will be used to help 
determine the responsiveness of the application.
    Applications which are complete and responsive may be subjected to 
a preliminary evaluation (streamline review) by a peer review 
committee, the Injury Research Grant Review Committee (IRGRC), to 
determine if the application is of sufficient technical and scientific 
merit to warrant further review by the IRGRC; CDC will withdraw from 
further consideration applications judged to be noncompetitive and 
promptly notify the principal investigator/program director and the 
official signing for the applicant organization. Those applications 
judged to be competitive will be further evaluated by a dual review 
process.
    All awards will be determined by the Director of the NCIPC based on 
priority scores assigned to applications by the IRGRC, recommendations 
by the secondary review committee, e.g., NCIPC's Advisory Committee for 
Injury Prevention and Control (ACIPC), consultation with NCIPC senior 
staff, and the availability of funds.
    1. The primary review will be a peer review conducted by the IRGRC. 
A committee consisting of no less than three reviewers with appropriate 
expertise using current NIH criteria (a scoring system of 100-500 
points) will evaluate the methods and scientific quality of the 
application. All categories are of equal importance, however, the 
application does not need to be strong in all categories to be judged 
likely to have a major scientific impact.
    Factors to be considered will include:
    a. Significance--Does this study address an important problem? If 
the aims of the application are achieved, how will scientific knowledge 
be advanced? What will be the effect of these studies on the concepts 
or methods that drive this field?
    b. Approach--Are the conceptual framework, design, methods, and 
analyses adequately developed, well integrated, and appropriate to the 
aims of the project and the resources available? Does the applicant 
acknowledge potential problem areas and consider alternative tactics? 
Does the project include plans to measure progress toward achieving the 
stated objectives? Is there an appropriate work plan included?
    c. Innovation--Does the project employ novel concepts, approaches 
or methods? Are the aims original and innovative? Does the project 
challenge or advance existing paradigms, or develop new methodologies 
or technologies?
    d. Investigator--Is the principal investigator appropriately 
trained and well suited to carry out this work? Is the proposed work 
appropriate to the experience level of the principal investigator? Is 
the name and role of a scientific mentor or collaborator described?
    e. Environment--Does the scientific environment in which the work 
will be done contribute to the probability of success? Is there 
evidence of institutional support? Is there an appropriate degree of 
commitment and cooperation of other interested parties as evidenced by 
letters detailing the nature and extent of the involvement?
    f. Ethical Issues. What provisions have been made for the 
protection of human subjects and the safety of the research 
environments? Where relevant, how does the applicant plan to handle 
issues of confidentiality and compliance with mandated reporting 
requirements, e.g., suspected child abuse? Does the application 
adequately address the requirements of 45 CFR part 46 for the 
protection of human subjects? (An application can be disapproved if the 
research risks are sufficiently serious and protection against risks is 
so inadequate as to make the entire application unacceptable.) The 
degree to which the applicant has met the CDC Policy requirements 
regarding the inclusion of women, ethnic, and racial groups in the 
proposed research (see Attachment 1, AR-2). This includes:
    (1) The proposed plan for the inclusion of both sexes and racial 
and ethnic minority populations for appropriate representation.
    (2) The proposed justification when representation is limited or 
absent.
    (3) A statement as to whether the design of the study is adequate 
to measure differences when warranted.
    (4) A statement as to whether the plans for recruitment and 
outreach for study participants include the process of establishing 
partnerships with community(ies) and recognition of mutual benefits.
    g. Study Samples. Are the samples sufficiently rigorously defined 
to permit complete independent replication at another site? Have the 
referral sources been described, including the definitions and 
criteria? What plans have been made to include women and minorities, 
and their subgroups as appropriate for the scientific goals of the 
research? How will the applicant deal with recruitment and retention of 
subjects?
    h. Dissemination. What plans have been articulated for 
disseminating findings?
    i. Measures of Effectiveness. The Peer Review Panel shall assure 
that measures set forth in the application are in accordance with CDC's 
performance plans. How adequately has the applicant addressed these 
measures?
    The IRGRC will also examine the appropriateness of the proposed 
project budget and duration in relation to the proposed research and 
the availability of data required for the project.
    2. The secondary review will be conducted by the Science and 
Program Review Subcommittee (SPRS) of the ACIPC. The ACIPC Federal 
agency experts will be invited to attend the


[[Page 6488]]


secondary review, and will receive modified briefing books (i.e., 
abstracts, strengths and weaknesses from summary statements, and 
project officer's briefing materials). ACIPC Federal agency experts 
will be encouraged to participate in deliberations when applications 
address overlapping areas of research interest, so that unwarranted 
duplication in federally funded research can be avoided and special 
subject area expertise can be shared. The NCIPC Division Associate 
Directors for Science (ADS) or their designees will attend the 
secondary review in a similar capacity as the ACIPC Federal agency 
experts to assure that research priorities of the announcement are 
understood and to provide background regarding current research 
activities. Only SPRS members will vote on funding recommendations, and 
their recommendations will be carried to the entire ACIPC for voting by 
the ACIPC members in closed session. If any further review is needed by 
the ACIPC, regarding the recommendations of the SPRS, the factors 
considered will be the same as those considered by the SPRS.
    The committee's responsibility is to develop funding 
recommendations for the NCIPC Director based on the results of the 
primary review, the relevance and balance of proposed research relative 
to the NCIPC programs and priorities, and to assure that unwarranted 
duplication of federally funded research does not occur. The secondary 
review committee has the latitude to recommend to the NCIPC Director, 
to reach over better-ranked proposals in order to assure maximal impact 
and balance of proposed research. The factors to be considered will 
include:
    a. The results of the primary review including the application's 
priority score as the primary factor in the selection process.
    b. The relevance and balance of proposed research relative to the 
NCIPC programs and priorities.
    c. The significance of the proposed activities in relation to the 
priorities and objectives stated in ``Healthy People 2010,'' the 
Institute of Medicine report, ``Reducing the Burden of Injury,'' and 
the ``CDC Injury Research Agenda'.


I. Other Requirements


Technical Reporting Requirements


    Provide CDC with an original plus two copies of:
    1. Annual progress report (The progress report will include a data 
requirement that demonstrates measures of effectiveness).
    2. A financial status report, no more than 90 days after the end of 
the budget period.
    3. A final financial report and performance report, no more than 90 
days after the end of the project period.
    4. At the completion of the project, the grant recipient will 
submit a brief (2,500 to 4,000 words written in non-scientific 
(laymen's) terms) summary highlighting the findings and their 
implications for injury prevention programs, policies, environmental 
changes, etc. The grant recipient will also include a description of 
the dissemination plan for research findings. This plan will include 
publications in peer-reviewed journals and ways in which research 
findings will be made available to stakeholders outside of academia, 
(e.g., state injury prevention program staff, community groups, public 
health injury prevention practitioners, and others). CDC will place the 
summary report and each grant recipient's final report with the 
National Technical Information Service (NTIS) to further the agency's 
efforts to make the information more available and accessible to the 
public.
    Send all reports to the Grants Management Specialist identified in 
the ``Where to Obtain Additional Information'' section of this 
announcement.


Additional Requirements


    The following additional requirements are applicable to this 
program. For a complete description of each, see Attachment 1 of the 
program announcement as posted on the CDC web site.


AR-1 Human Subjects Certification
AR-2 Requirements for inclusion of Women and Racial and Ethnic 
Minorities in Research
AR-3 Animal Subjects Requirement
AR-9 Paperwork Reduction Requirements
AR-10 Smoke-Free Workplace Requirement
AR-11 Healthy People 2010
AR-12 Lobbying Restrictions
AR-13 Prohibition on Use of CDC funds for Certain Gun Control 
Activities
AR-21 Small, Minority, and Women-owned Business
AR-22 Research Integrity


    Executive Order 12372 does not apply to this program.


J. Where To Obtain Additional Information


    This and other CDC announcements, the necessary applications, and 
associated forms can be found on the CDC web site, Internet address: 
http://www.cdc.gov.
    Click on ``Funding,'' then ``Grants and Cooperative Agreements.''
    For general questions about this announcement, contact: Technical 
Information Management, CDC Procurement and Grants Office, 2920 
Brandywine Rd, Atlanta, GA 30341-4146. Telephone: 770-488-2700.
    For business management and budget assistance, contact: Richard 
Jenkins, Grants Management Specialist, Procurement and Grants Office, 
Centers for Disease Control and Prevention, 2920 Brandywine Road, 
Atlanta, GA 30341-4146. Telephone: 770-488-2604. E-mail address: 
rbj3@cdc.gov.
    For program technical assistance, contact: Tom Voglesonger, Program 
Manager, Office of the Director, National Center for Injury Prevention 
and Control, Centers for Disease Control and Prevention (CDC), 4770 
Buford Highway, NE., Mailstop K-02, Atlanta, GA 30341-3724. Telephone: 
770-488-4823. Internet address: TVoglesonger@cdc.gov.


    Dated: February 1, 2003.
Sandra R. Manning,
CGFM, Director, Procurement and Grants Office, Centers for Disease 
Control and Prevention.
[FR Doc. 03-3027 Filed 2-6-03; 8:45 am]

BILLING CODE 4163-18-P