[Federal Register: April 18, 2008 (Volume 73, Number 76)]
[Notices]
[Page 21135-21136]
From the Federal Register Online via GPO Access [wais.access.gpo.gov]
[DOCID:fr18ap08-60]
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DEPARTMENT OF HEALTH AND HUMAN SERVICES
Agency for Toxic Substances and Disease Registry
[ATSDR-243]
Availability of Two Interaction Profiles [Draft Documents]
AGENCY: Agency for Toxic Substances and Disease Registry (ATSDR),
Department of Health and Human Services (DHHS).
ACTION: Notice of availability for public comments.
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SUMMARY: This notice announces the availability of two interaction
profiles prepared by ATSDR for public comments [draft documents].
DATES: The interaction profiles will be available to the public on or
about April 15, 2008.
ADDRESSES: The documents will be available on ATSDR's Web site at
http://www.atsdr.cdc.gov.
FOR FURTHER INFORMATION CONTACT: Please submit comments regarding the
information contained in the profiles to Dr. Hana Pohl, Division of
Toxicology and Environmental Medicine, Agency for Toxic Substances and
Disease Registry, Mailstop F-32, 1600 Clifton Road, NE., Atlanta,
Georgia 30333, telephone (888) 422-8737.
SUPPLEMENTARY INFORMATION: ATSDR develops interaction profiles for
hazardous substances found at the National Priority List (NPL) sites
under Section 104(i)(3) and (5) of the Comprehensive Environmental
Response, Compensation, and Liability Act of 1980 (CERCLA). This public
law mandates that ATSDR assess whether or not adequate information on
health effects is available for priority hazardous substances. Where
such information is not available or under development, ATSDR shall, in
cooperation with the National Toxicology Program, initiate a research
program to determine these health effects. The act further directs
that, where feasible, ATSDR shall develop methods to determine the
health effects of these priority hazardous substances in combination
with other substances commonly found with them.
To carry out these legislative mandates, ATSDR has developed a
chemical mixtures program. As part of the mixtures program, ATSDR
developed a guidance manual that outlines the latest methods for
mixtures health assessment. In addition, a series of documents called
``interaction profiles'' is being developed for certain priority
mixtures that are of special concern to ATSDR. To recommend approaches
for the exposure-based assessment of the potential hazard to public
health, an interaction profile evaluates data on the toxicology of the
whole priority mixture, if available, and on the joint toxic action of
the chemicals in the mixture.
The entire interaction profile development process is as follows:
ATSDR selects substances/chemicals for development of
interaction profiles through inter/intra agency communications
collaboration and literature reviews.
After the selection, a letter is sent to individuals and
agencies on ATSDR's mailing list providing notice of ATSDR's intent to
create an interaction profile.
A notice is posted in the Federal Register to inform the
public of ATSDR's intent to develop a particular interaction profile.
The draft interaction profile undergoes both internal and
external peer review.
A Federal Register notice announces the release of the
official draft for public comment.
ATSDR posts a link to the draft interaction profile on its
Web site, giving the public an opportunity to provide comments.
ATSDR reviews all public comments and revises the draft,
as appropriate, before issuing the final version.
The following documents will be available to the public on or about
April 15, 2008.
Document 1
Interaction Profile for Carbon Monoxide, Formaldehyde, Methylene
Chloride, Nitrogen Dioxide, and Tetrachloroethylene.
Document 2
Interaction Profile for Chloroform, 1,1-Dichloroethylene,
Trichloroethylene, and Vinyl Chloride.
Document 1 evaluates a mixture of chemicals often found in indoor
air based on the information regarding residential (i.e., background)
exposures provided by the U.S. Environmental Protection Agency. Data on
background exposures can be used for evaluations of total exposures in
populations living around hazardous waste sites.
Document 2 evaluates a mixture of volatile organic chemicals. This
particular mixture was chosen as a subject for the interaction profile
because these chemicals are among the top 10 chemicals found in water
around hazardous waste sites. Consequently, they are also encountered
in combinations.
The two interaction profiles underwent external peer review. These
documents were also reviewed by the ATSDR's Interagency Workgroup on
Mixtures.
The documents will be available for public comments for 90 days.
[[Page 21136]]
Dated: April 11, 2008.
Tim Hack,
Deputy Director, Office of Policy, Planning and Evaluation, National
Center for Environmental Health/Agency for Toxic Substances and Disease
Registry.
[FR Doc. E8-8167 Filed 4-17-08; 8:45 am]
BILLING CODE 4163-70-P