[Federal Register Volume 74, Number 140 (Thursday, July 23, 2009)]
[Notices]
[Pages 36493-36494]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: E9-17527]
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DEPARTMENT OF HEALTH AND HUMAN SERVICES
Agency for Toxic Substances and Disease Registry
[ATSDR-254]
Notice of Development of Set 23 Toxicological Profiles
AGENCY: Agency for Toxic Substances and Disease Registry (ATSDR),
Department of Health and Human Services (HHS).
ACTION: Notice.
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SUMMARY: This notice announces the development of Set 23 Toxicological
Profiles. Set 23 Toxicological Profiles consists of three new drafts
and two updated drafts. These profiles will be available to the public
on or about October 17, 2009. Electronic access to these documents will
be available at the ATSDR Web site: http://www.atsdr.cdc.gov/toxpro2.html.
Set 23 Toxicological Profiles
The following toxicological profiles are now being developed:
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Toxicological profile CAS No.
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1. Acrylamide*............................... 79-06-1
2. Carbon Monoxide*.......................... 630-08-0
3. 1,3-Butadiene............................. 106-99-0
4. Phosphate Ester Flame Retardants*......... 126-73-8, 126-71-6, 78-51-3, 115-86-6, 13674-84-5, 13674-87-8,
115-96-8
5. Vanadium.................................. 7440-62-2
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* Denotes new profile.
SUPPLEMENTARY INFORMATION: The Superfund Amendments and Reauthorization
Act of 1986 (SARA) (42 U.S.C. 9601 et seq.) amended the Comprehensive
Environmental Response, Compensation, and Liability Act of 1980 (CERCLA
or Superfund) (42 U.S.C. 9601 et seq.) by establishing certain
requirements for ATSDR and the U.S. Environmental Protection Agency
(EPA) with regard to hazardous substances that are most commonly found
at facilities on the CERCLA National Priorities List (NPL). Among these
statutory requirements is a mandate for the Administrator of ATSDR to
prepare toxicological profiles for each substance included on the
Priority List of Hazardous Substances (http://www.atsdr.cdc.gov/cercla/07list.html). This list names 275 hazardous substances that pose the
most significant potential threat to human health as determined by
ATSDR and EPA. The availability of the revised list of the 275 priority
substances was announced in the Federal Register on March 6, 2008 (73
FR 12178). For prior versions of the list of substances, see Federal
Register notices dated April 17, 1987 (52 FR 12866); October 20, 1988
(53 FR 41280); October 26, 1989 (54 FR 43619); October 17, 1990 (55 FR
42067); October 17, 1991 (56 FR 52166); October 28, 1992 (57 FR 48801);
February 28, 1994 (59 FR 9486); April 29, 1996 (61 FR 18744; November
17, 1997 (62 FR 61332); October 21, 1999 (64 FR 56792); October 25,
2001 (66 FR 54014); November 7, 2003 (68 FR 63098); and December 7,
2005 (70 FR 70284).
The Set 23 Toxicological Profiles for 1,3-Butadiene and Vanadium
are updates of previously published profiles for NPL priority
substances. In addition, to address emerging public health concerns
related to substances not currently on the NPL, ATSDR is also
developing Set 23 Toxicological Profiles for Carbon Monoxide,
Acrylamide, and Phosphate Ester Flame Retardants. Carbon monoxide is a
toxic gas produced from the incomplete combustion of carbon-based
fuels. Because it is colorless and odorless, toxicity can occur with no
indication that exposure is occurring. Thousands of hospitalizations
and hundreds of deaths occur every year as a result of inadvertent
exposure to carbon monoxide. Acrylamide is a known animal carcinogen
that is widely used in industry to synthesize polyacrylamides.
Acrylamide also occurs naturally in a few foods, is formed in many
foods as a byproduct of numerous cooking processes, and has been
detected recently in human biomonitoring studies. Phosphate ester flame
retardants comprise a large group of structurally related chemicals
with increasing uses in clothing, fabrics, furniture, and structural
components. However, there is an increasing body of information
regarding exposures, body burdens, and toxicity related to this group
of chemicals.
[[Page 36494]]
Notice of the availability of drafts of these two updated and three
new toxicological profiles for public review and comment will be
published in the Federal Register on/or about October 17, 2009, with
notice of a 90-day public comment period for each profile, starting
from the actual release date. Following the close of the comment
period, chemical-specific comments will be addressed, and, where
appropriate, changes will be incorporated into each profile.
FOR FURTHER INFORMATION CONTACT: Commander Jessilynn B. Taylor,
Division of Toxicology and Environmental Medicine, Agency for Toxic
Substances and Disease Registry, 1600 Clifton Road, NE., Mail Stop F-
32, Atlanta, GA 30333, telephone 770-488-3313.
Ken Rose,
Director, Office of Policy, Planning and Evaluation, National Center
for Environmental Health/Agency for Toxic Substances and Disease
Registry.
[FR Doc. E9-17527 Filed 7-22-09; 8:45 am]
BILLING CODE 4163-70-P