[Federal Register: April 15, 2009 (Volume 74, Number 71)]
[Notices]
[Page 17579-17585]
From the Federal Register Online via GPO Access [wais.access.gpo.gov]
[DOCID:fr15ap09-138]
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ENVIRONMENTAL PROTECTION AGENCY
[EPA-HQ-OPPT-2004-0109; FRL-8399-7]
Final List of Initial Pesticide Active Ingredients and Pesticide
Inert Ingredients to be Screened Under the Federal Food, Drug, and
Cosmetic Act
AGENCY: Environmental Protection Agency (EPA).
ACTION: Notice.
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SUMMARY: Section 408(p) of the Federal Food, Drug, and Cosmetic Act
(FFDCA) directs EPA to develop a chemical screening program using
appropriate validated test systems and other scientifically relevant
information to determine whether certain substances may have hormonal
effects. In September 2005, EPA published its approach for selecting
the initial list of chemicals for which testing will be required under
the Endocrine Disruptor Screening Program (EDSP) and in June 2007, EPA
published the draft list of the first group of chemicals proposed for
screening in the Agency's EDSP. This document presents the final list
of the first group of chemicals that will be screened in the Agency's
EDSP. The list was produced using the approach described in the
September 2005 notice and considers comments received in response to
the June 2007 draft list. The list includes chemicals that the Agency,
in its discretion, has decided should be tested first, based upon
exposure potential. The Agency deleted 6 chemicals from the original
list of 73 based upon recent information showing that the chemicals are
no longer expected to be found in 3 exposure pathways. The first group
of 67 chemicals identified for testing includes pesticide active
ingredients and High Production Volume (HPV) chemicals used as
pesticide inert ingredients (also known as other ingredients). This
list should not be construed as a list of known or likely endocrine
disruptors. Nothing in the approach for generating the initial list
provides a basis to infer that by simply being on this list these
chemicals are suspected to interfere with the endocrine systems of
humans or other species, and it would be inappropriate to do so. This
document does not describe other aspects of the EDSP such as the
administrative procedures EPA will use to require testing, which is
addressed in a separate notice published in today's Federal Register.
FOR FURTHER INFORMATION CONTACT: Linda Phillips, Office of Science
Coordination and Policy (7203M), Environmental Protection Agency, 1200
Pennsylvania Ave., NW., Washington, DC 20460-0001; telephone number:
(202) 564-1264; e-mail address: phillips.linda@epa.gov.
SUPPLEMENTARY INFORMATION:
I. General Information
A. Does this Action Apply to Me?
This action is directed to the public in general. You may be
potentially affected by this action if you produce, manufacture, use,
consume, work with, or import pesticide chemicals. To determine whether
you or your business may be affected by this action, you should
carefully examine section 408(p) of FFDCA, 21 U.S.C. 346a(p).
Potentially affected entities, using the North American Industrial
Classification System (NAICS) codes to assist you and others in
determining whether this action might apply to certain entities, may
include, but are not limited to:
Chemical manufacturers, importers and processors (NAICS
code 325), e.g., persons who manufacture, import or process chemical
substances.
Pesticide, fertilizer, and other agricultural chemical
manufacturers (NAICS code 3253), e.g., persons who manufacture, import
or process pesticide, fertilizer and agricultural chemicals.
Scientific research and development services (NAICS code
5417), e.g., persons who conduct testing of chemical substances for
endocrine effects.
This listing is not intended to be exhaustive, but rather provides
a guide for readers regarding entities likely to be affected by this
action. Other types of entities not listed in this unit could also be
affected. If you have any questions regarding the applicability of this
action to a particular entity, consult the person listed under FOR
FURTHER INFORMATION CONTACT.
B. How Can I Get Copies of this Document and Other Related Information?
1. Docket. EPA has established a docket for this action under
docket identification (ID) number EPA-HQ-OPPT-2004-0109. All documents
in the docket are listed in the docket index available in
regulations.gov. To access the electronic docket, go to http://
www.regulations.gov, select ``Advanced Search,'' then ``Docket
Search.'' Insert the docket ID number where indicated and select the
``Submit'' button. Follow the instructions on the regulations.gov
website to view the docket index or access available documents.
Although listed in the index, some information is
[[Page 17580]]
not publicly available, e.g., Confidential Business Information (CBI)
or other information whose disclosure is restricted by statute. Certain
other material, such as copyrighted material, will be publicly
available only in hard copy. Publicly available docket materials are
available electronically at http://www.regulations.gov, or, if only
available in hard copy, at the OPPT Docket. The OPPT Docket is located
in the EPA Docket Center (EPA/DC) at Rm. 3334, EPA West Bldg., 1301
Constitution Ave., NW., Washington, DC. The EPA/DC Public Reading Room
hours of operation are 8:30 a.m. to 4:30 p.m., Monday through Friday,
excluding Federal holidays. The telephone number of the EPA/DC Public
Reading Room is (202) 566-1744, and the telephone number for the OPPT
Docket is (202) 566-0280. Docket visitors are required to show
photographic identification, pass through a metal detector, and sign
the EPA visitor log. All visitor bags are processed through an X-ray
machine and subject to search. Visitors will be provided an EPA/DC
badge that must be visible at all times in the building and returned
upon departure.
2. Electronic access. You may access this Federal Register document
electronically through the EPA Internet under the Federal Register
listings at http://www.epa.gov/fedrgstr. You may access information
about the EDSP at http://www.epa.gov/scipoly/oscpendo/index.htm.
II. Introduction
A. What Action is the Agency Taking?
EPA is announcing the final list of the first group of chemicals
that will be screened in the Agency's Endocrine Disruptor Screening
Program (EDSP) based on the approach described in the Federal Register
notice of September 27, 2005 (70 FR 56449) (FRL-7716-9), and
consideration of comments received on the draft list of chemicals
published in the Federal Register notice of June 18, 2007 (72 FR 33486)
(FRL-8129-3). The approach focused on human exposure-related factors
rather than a combination of exposure- and effects-related factors. The
approach did not include a literature search for or consideration of
any data on potential endocrine effects. Because EPA developed this
list of chemicals based upon exposure potential, it should not be
construed as a list of known or likely endocrine disruptors, and it
would be inappropriate to do so. Nothing in the approach for generating
the initial list provides a basis to infer that by simply being on this
list these chemicals are suspected to interfere with the endocrine
systems of humans or other species.
The first group of chemicals to be tested consists of chemicals
that section 408(p) of the Federal Food, Drug, and Cosmetic Act (FFDCA)
requires be screened, i.e., pesticide active ingredients and chemicals
used as pesticide inert ingredients (also known as other ingredients)
that are also HPV chemicals. EPA anticipates that it may, in the
future, modify its approach to selecting chemicals for screening.
Information and factors that EPA may consider in selecting chemicals
could include: Public input; the results of testing chemicals on the
initial list; management considerations to increase the integration of
screening with other regulatory activities within the Agency;
implementation considerations flowing from a decision to extend
screening to additional categories of chemicals (e.g., non-pesticide
chemical substances); and the availability of new priority setting
tools (e.g., High Throughput Pre-screening or Quantitative Structure
Activity Relationships models). More information on EPA's priority
setting approach is available at http://www.epa.gov/scipoly/oscpendo/
pubs/prioritysetting.
EPA's general focus in the approach for the initial list was on
pesticide active ingredients and inert ingredients with relatively
greater potential for human exposure. The emphasis on human exposure
does not necessarily mean that the list will not contain substances
that may not also have potentially high levels of environmental
exposure to ecological receptors. This Federal Register document
identifies the chemicals that were removed from the draft list and
presents the final list of the first group of chemicals that will be
screened in the Agency's EDSP in alphabetical order. This document does
not describe other aspects of the EDSP such as the administrative
procedures EPA will use to require testing, the validated tests and
battery that will be included in the EDSP, or the timeframe for
requiring the testing or receiving the data. These topics will be
addressed in separate notices published in the Federal Register, with
the administrative procedures described in a separate notice published
in today's Federal Register.
B. What is the Agency's Authority for Taking this Action?
Section 408(p) of FFDCA requires EPA to ``develop a screening
program, using appropriate validated test systems and other
scientifically relevant information, to determine whether certain
substances may have an effect in humans that is similar to an effect
produced by a naturally occurring estrogen, or such other endocrine
effect as [EPA] may designate.'' (21 U.S.C. 346a(p)). The statute
generally requires EPA to ``provide for the testing of all pesticide
chemicals.'' (21 U.S.C. 346a(p)(3)). However, EPA is authorized to
exempt a chemical, by order upon a determination that ``the substance
is anticipated not to produce any effect in humans similar to an effect
produced by a naturally occurring estrogen.'' (21 U.S.C. 346a(p)(4)).
``Pesticide chemical'' is defined as ``any substance that is a
pesticide within the meaning of the Federal Insecticide, Fungicide, and
Rodenticide Act (FIFRA), including all active and inert ingredients of
such pesticide.'' (21 U.S.C. 321(q)(1)).
III. Background
EPA developed its EDSP in response to the Congressional mandate in
section 408(p) of FFDCA to ``develop a screening program. . .to
determine whether certain substances may have an effect in humans that
is similar to an effect produced by a naturally occurring estrogen, or
such other endocrine effects as [EPA] may designate'' (21 U.S.C.
346a(p)). When carrying out the program, the statute requires EPA to
``provide for the testing of all pesticide chemicals.'' The statute
also provides EPA with discretionary authority to ``provide for the
testing of any other substance that may have an effect that is
cumulative to an effect of a pesticide chemical if the Administrator
determines that a substantial population may be exposed to such a
substance.'' In addition, section 1457 of the Safe Drinking Water Act
(SDWA) provides EPA with discretionary authority to provide for
testing, under the FFDCA section 408(p) screening program, ``of any
other substances that may be found in sources of drinking water if the
Administrator determines that a substantial population may be exposed
to such substance.''
EPA initially set forth the EDSP in the August 11, 1998 Federal
Register notice (63 FR 42852) (FRL-6021-3), and solicited public
comment on the program in the December 28, 1998 Federal Register notice
(63 FR 71542) (FRL-6052-9). The program set forth in these notices was
based on the recommendations of the Endocrine Disruptor Screening and
Testing Advisory Committee (EDSTAC), which was chartered under the
Federal Advisory Committee Act (FACA), 5 U.S.C. App.2, section 9(c).
The EDSTAC was comprised of members representing the commercial
chemical and pesticides industries, Federal and State agencies,
[[Page 17581]]
worker protection and labor organizations, environmental and public
health groups, and research scientists.
EDSTAC recommended that EPA's program address both potential human
and ecological effects; examine effects on estrogen, androgen, and
thyroid hormone-related processes; and include non-pesticide chemicals,
contaminants, and mixtures in addition to pesticides (Ref. 1). Based on
these recommendations, EPA developed a two-tiered approach, referred to
as the EDSP. The purpose of Tier 1 screening (referred to as
``screening'') is to identify substances that have the potential to
interact with the estrogen, androgen, or thyroid hormone systems using
a battery of assays. The purpose of Tier 2 testing (referred to as
``testing'') is to identify and establish a dose-response relationship
for any adverse effects that might result from the interactions
identified through the Tier 1 assays. EDSTAC also recommended that EPA
establish a priority-setting approach for choosing chemicals to undergo
Tier 1 screening. EPA described this approach in the Federal Register
of September 2005. More information on EPA's priority setting approach
for the EDSP is available at http://www.epa.gov/scipoly/oscpendo/
prioritysetting.
EPA currently is implementing its EDSP in three major parts that
are being developed in parallel.
1. Assay validation. Under FFDCA section 408(p), EPA is required to
use ``appropriate validated test systems and other scientifically
relevant information'' to determine whether substances may have
estrogenic effects in humans or other endocrine effects as the
Administrator may designate. Validation is defined as the process by
which the reliability and relevance of test methods are evaluated for
the purpose of supporting a specific use. The proposed EDSP Tier 1
screening battery of assays was presented to the FIFRA Scientific
Advisory Panel (SAP) during a public meeting on March 25-27, 2008. The
FIFRA SAP report covering the meeting is available at http://
www.epa.gov/scipoly/sap/meetings/2008/march/minutes2008-03-25.pdf. The
final Tier 1 battery will be announced in a separate Federal Register
document that the Agency anticipates issuing in spring 2009. EPA is
also in the process of developing and validating Tier 2 tests. The
status of each assay can be viewed on the EDSP website in the Assay
Status table: http://www.epa.gov/scipoly/oscpendo/pubs/assayvalidation/
status.htm.
2. Priority setting. EPA described its priority setting approach
for the first group of pesticide chemicals to be tested in the Federal
Register of September 2005, and proposed the draft list of initial
chemicals for review and public comment in the Federal Register notice
of June 18, 2007 (72 FR 33486) (FRL-8129-3). The Agency is responding
to the public comments in a separate document (Ref. 2) posted in the
docket that was established for this action (EPA-HQ-OPPT-2004-0109).
This document today announces the final list of initial chemicals to
undergo Tier 1 screening. More information on EPA's priority setting
approach for the EDSP is available at http:/ /www.epa.gov/scipoly/
oscpendo/prioritysetting.
3. Procedures. EPA intends to commence Tier 1 screening of the
first group of pesticide chemicals by issuing test orders under FFDCA
section 408(p) to chemical companies identified as the manufacturer or
processor of the identified chemicals and/or the pesticide registrants.
EPA published draft policies and procedures in the Federal Register
notice of December 13, 2007 (72 FR 70842) (FRL-8340-3), that describes
the procedures that EPA will use to issue orders, the procedures that
Order recipients would use to respond to the order, how data protection
and compensation will be addressed in the test orders, and other
related procedures or policies. In addition, EPA developed a draft
template for the test order and a draft information collection request
(ICR) to obtain the necessary clearances under the Paperwork Reduction
Act (PRA). Elsewhere is this issue of the Federal Register, the Agency
is publishing the final policies and procedures, and the announcement
of the ICR's submission to OMB.
Based on the current timing for each of the three major parts of
the EDSP, the Agency intends to initiate the EDSP Tier 1 screening for
the first group of pesticide chemicals by issuing test orders in 2009.
This document deals only with the final list of chemicals initially
selected to go through screening in the Tier 1 assays.
IV. Development of the Initial List of Chemicals
The development of the initial list of chemicals is described in
detail in the September 2005 and the June 2007 Federal Register
notices.
Comments on the Final List
EPA received comments on the proposed initial list including
suggestions for additional chemicals, questions regarding the need for
Tier 1 screening data, the future chemical selection approach, and
claims for removal of chemicals from the list. One of the main concerns
was whether and how EPA would consider existing data in determining
what screening assays were necessary. Although EPA does not currently
intend to tailor test orders based on existing information, as
articulated in the Reponse to Comments on the Draft List of Initial
Pesticide Active Ingredients and Pesticide Inert Ingredients to be
Screened under the Federal Food, Drug, and Cosmetic Act (Ref. 2), EPA
will provide a mechanism whereby test order recipients and the public
can provide information on specific chemicals for which test orders are
issued. A test order recipient can elect to cite or submit existing
data the recipient believes can be used to satisfy part or all of the
Tier 1 Order and/or otherwise inform the determination as to whether
the substance may have an effect that is similar to an effect produced
by a substance that interacts with the estrogen, androgen and/or
thyroid hormonal systems. In order for EPA to review the submission in
a timely manner, in submitting or citing existing data, the order
recipient should consider providing an explanation of the relevance of
the data to the order, including, where appropriate, a cogent and
complete rationale for why it believes the information is sufficient to
satisfy part or all of the Tier 1 Order. The recipient's response to
test orders for Tier 1 assays will be evaluated by EPA to determine
whether the cited data can be used to satisfy the order and/or
otherwise inform the Tier 1 determination. This will require a case-by-
case determination of whether the information submitted is of high
quality and achieves the objective of Tier 1. This approach is
consistent with ensuring effective and efficient use of societal and
government resources in generating and reviewing data, as well as
minimizing the use of animals in regulatory testing, to achieve the
information base needed to support a specified objective.
These comments have been addressed in a document, entitled Reponse
to Comments on the Draft List of Initial Pesticide Active Ingredients
and Pesticide Inert Ingredients to be Screened under the Federal Food,
Drug, and Cosmetic Act (Ref. 2), available in the docket for this
action under docket ID number EPA-HQ-OPPT-2004-0109. In addition, the
Agency has written a paper entitled EPA's Approach for Considering
Other Scientifically Relevant Information (OSRI) under the Endocrine
Disruptor Screening Program. This paper was developed by EPA to provide
guidance to EPA staff and managers who will be reviewing the responses
to Tier 1 Orders issued under the EDSP, and may also be of interest to
[[Page 17582]]
parties considering whether to submit other scientically relevant
information to EPA. This paper provides general guidance and is not
binding on either EPA or any outside parties. Anyone may provide other
scientifically relevant information, and the Agency will assess the
information for appropriateness on a case-by-case basis, responding to
the submitter in writing, and making EPA's determination publicly
available. A copy of this paper has been placed in the Docket for the
Policies and Procedures for the Initial EDSP Screening (Docket ID
number EPA-HQ-OPPT-2007-1080).
V. The Final List of Initial Pesticide Active Ingredients and Pesticide
Inert Ingredients (also known as other ingredients) to be Considered
for Screening under the FFDCA
A. Chemicals Removed from the Draft List of Proposed Chemicals for
Initial Screening
No HPV pesticide inert ingredients were removed. Six pesticide
active chemicals were removed from the draft list of proposed chemicals
for initial screening that resulted in this final list. Two of the
chemicals, azinphos-methyl and fenvalerate, were removed from the list
because all uses of these pesticides have ended or will end before Tier
2 data could be generated in 2012. The remaining four chemicals were
removed based on a reassessment of their uses that confirmed that they
would only be expected to be present in two, instead of three, exposure
pathways (i.e., the criterion for selecting chemicals for the initial
list was the presence of the chemical in at least three of the four
exposure pathways where the food and occupational exposure pathways
were represented). Specifically, aldicarb, allethrin, dichlorvos, and
methiocarb, were removed from the initial list because changes in their
use and application methods has eliminated the potential for exposure
in one or more pathways. As described in the September 2005 and June
2007 Federal Register notices, higher occupational exposure was based
on the potential for agricultural workers to come into contact with a
pesticide residue after its application (e.g., a worker pruning fruit
trees or harvesting a crop). For occupational exposure, EPA relied on
databases that assessed the exposure potential for workers who might
enter a field or orchard after treatment with pesticides. In two cases
(aldicarb and methiocarb), EPA regulation has either eliminated
specific uses or changed the method of application which has eliminated
or reduced the potential for post-application exposure below the
threshold described in the previous Federal Register notices (September
2005 and June 2007) where EPA identified 14 work activities/crop
categories (e.g., tree fruit crops) having the highest transfer
coefficients. In the case of aldicarb, the pesticide can only be
applied by soil incorporation while in the case of methiocarb, the
remaining agricultural uses are granular applications in nurseries and
greenhouses. There are currently no registered uses of dichlorvos that
will result in occupational exposure pathways associated with the
selected 14 work activities/crop categories having the highest transfer
coefficients. Finally, current registrations for allethrin and
methiocarb no longer include uses on food crops. Since these four
chemicals no longer meet the listing criteria, they are being deleted
from the initial list of chemicals to be screened. However, it should
be noted that all pesticidal chemicals will eventually be screened for
their potential to interact with the endocrine system as required by
the statute. (21 U.S.C. 346a(p)(3)).
Table 1 presents an alphabetized list of the six pesticide active
ingredients that were removed from the original list of 73 chemicals
recommended for Tier 1 screening in the EDSP and provides the rationale
for their removal from the list.
Table 1.--Chemicals Removed From the Initial List of Chemicals for Tier
1 Screening in the EDSP (These are all pesticide active ingredients)
------------------------------------------------------------------------
Reason for Removal
Chemical Name CAS Number from Testing List
------------------------------------------------------------------------
Aldicarb 116063 The initial
analysis using the
exposure based
criteria for
chemical selection
found aldicarb in
three exposure
pathways: Food,
water, and
occupational. Due
to changes in the
use pattern,
aldicarb is only
present in two
exposure pathways
(food and water)
and will not be
tested at this
time.
------------------------------------------------------------------------
Allethrin 584792 The initial
analysis using the
exposure based
criteria for
chemical selection
found allethrin in
three exposure
pathways: Food,
residential, and
occupational.
There are
currently no
registered food
uses for this
chemical.
Allethrin is only
present in two
exposure pathways
(occupational and
residential) and
will not be tested
at this time.
------------------------------------------------------------------------
Azinphos-Methyl 86500 The initial
analysis using the
exposure based
criteria for
chemical selection
found azinphos-
methyl in three
exposure pathways:
Food, water, and
occupational. All
uses of azinphos-
methyl will cease
by 2012. For this
reason azinphos-
methyl will not be
tested.
------------------------------------------------------------------------
Dichlorvos 62737 The initial
analysis using the
exposure based
criteria for
chemical selection
found dichlorvos
in three exposure
pathways: Food,
residential, and
occupational.
There are
currently no
registered uses of
dichlorvos that
will result in
occupational
exposure pathways
associated with
the selected 14
work activities/
crop categories
having the highest
transfer
coefficients.
Dichlorvos is only
present in two
exposure pathways
(food and
residential) and
will not be tested
at this time.
------------------------------------------------------------------------
[[Page 17583]]
Fenvalerate 51630581 The initial
analysis using the
exposure based
criteria for
chemical selection
found fenvalerate
in three exposure
pathways: Food,
residential, and
occupational.
There are
currently no
registered food
uses for this
chemical. In
addition, the
registrant
voluntarily ceased
production of
fenvalerate. As of
the August 2007
deadline, no end
use registrants
have indicated a
source of the
technical grade
active ingredient.
The few remaining
products under
existing stocks
are primarily for
residential use
with a few labeled
for commercial use
in food handling
establishments.
For this reason,
fenvalerate will
not be tested.
------------------------------------------------------------------------
Methiocarb 2032657 The initial
analysis using the
exposure based
criteria for
chemical selection
found methiocarb
in four exposure
pathways: Food,
water,
residential, and
occupational. Due
to changes in the
use pattern,
methiocarb is only
present in two
exposure pathways
(water and
residential) and
will not be tested
at this time.
------------------------------------------------------------------------
B. The Final List of Pesticide Chemicals for Initial Screening
Table 2 presents an alphabetized list of the 67 pesticide active
ingredients and HPV/pesticide inert chemicals for screening in the
EDSP. Because this list of chemicals was selected on the basis of
exposure potential only, it should neither be construed as a list of
known or likely endocrine disruptors nor characterized as such.
Table 2.--Final List of Chemicals for Tier 1 Screening in the EDSP
----------------------------------------------------------------------------------------------------------------
Pesticide Active
Chemical Name CAS Number Ingredient HPV/Inert
----------------------------------------------------------------------------------------------------------------
2,4-D 94757 x .................
----------------------------------------------------------------------------------------------------------------
4,7-Methano-1H-isoindole-1,3(2H)-dione, 2-(2- 113484 x .................
ethylhexyl)-3a,4,7,7a-tetrahydro-
----------------------------------------------------------------------------------------------------------------
Abamectin 71751412 x .................
----------------------------------------------------------------------------------------------------------------
Acephate 30560191 x .................
----------------------------------------------------------------------------------------------------------------
Acetone 67641 x
----------------------------------------------------------------------------------------------------------------
Atrazine 1912249 x .................
----------------------------------------------------------------------------------------------------------------
Benfluralin 1861401 x .................
----------------------------------------------------------------------------------------------------------------
Bifenthrin 82657043 x .................
----------------------------------------------------------------------------------------------------------------
Butyl benzyl phthalate 85687 x
----------------------------------------------------------------------------------------------------------------
Captan 133062 x .................
----------------------------------------------------------------------------------------------------------------
Carbamothioic acid, dipropyl-, S-ethyl ester 759944 x .................
----------------------------------------------------------------------------------------------------------------
Carbaryl 63252 x .................
----------------------------------------------------------------------------------------------------------------
Carbofuran 1563662 x .................
----------------------------------------------------------------------------------------------------------------
Chlorothalonil 1897456 x .................
----------------------------------------------------------------------------------------------------------------
Chlorpyrifos 2921882 x .................
----------------------------------------------------------------------------------------------------------------
Cyfluthrin 68359375 x .................
----------------------------------------------------------------------------------------------------------------
Cypermethrin 52315078 x .................
----------------------------------------------------------------------------------------------------------------
DCPA (or chlorthal-dimethyl) 1861321 x .................
----------------------------------------------------------------------------------------------------------------
Diazinon 333415 x .................
----------------------------------------------------------------------------------------------------------------
Dibutyl phthalate 84742 x
----------------------------------------------------------------------------------------------------------------
Dichlobenil 1194656 x .................
----------------------------------------------------------------------------------------------------------------
[[Page 17584]]
Dicofol 115322 x .................
----------------------------------------------------------------------------------------------------------------
Diethyl phthalate 84662 x
----------------------------------------------------------------------------------------------------------------
Dimethoate 60515 x .................
----------------------------------------------------------------------------------------------------------------
Dimethyl phthalate 131113 x
----------------------------------------------------------------------------------------------------------------
Di-sec-octyl phthalate 117817 x
----------------------------------------------------------------------------------------------------------------
Disulfoton 298044 x .................
----------------------------------------------------------------------------------------------------------------
Endosulfan 115297 x .................
----------------------------------------------------------------------------------------------------------------
Esfenvalerate 66230044 x .................
----------------------------------------------------------------------------------------------------------------
Ethoprop 13194484 x .................
----------------------------------------------------------------------------------------------------------------
Fenbutatin oxide 13356086 x .................
----------------------------------------------------------------------------------------------------------------
Flutolanil 66332965 x .................
----------------------------------------------------------------------------------------------------------------
Folpet 133073 x .................
----------------------------------------------------------------------------------------------------------------
Gardona (cis-isomer) 22248799 x .................
----------------------------------------------------------------------------------------------------------------
Glyphosate 1071836 x .................
----------------------------------------------------------------------------------------------------------------
Imidacloprid 138261413 x .................
----------------------------------------------------------------------------------------------------------------
Iprodione 36734197 x .................
----------------------------------------------------------------------------------------------------------------
Isophorone 78591 x
----------------------------------------------------------------------------------------------------------------
Linuron 330552 x .................
----------------------------------------------------------------------------------------------------------------
Malathion 121755 x .................
----------------------------------------------------------------------------------------------------------------
Metalaxyl 57837191 x .................
----------------------------------------------------------------------------------------------------------------
Methamidophos 10265926 x .................
----------------------------------------------------------------------------------------------------------------
Methidathion 950378 x .................
----------------------------------------------------------------------------------------------------------------
Methomyl 16752775 x .................
----------------------------------------------------------------------------------------------------------------
Methyl ethyl ketone 78933 x
----------------------------------------------------------------------------------------------------------------
Methyl parathion 298000 x .................
----------------------------------------------------------------------------------------------------------------
Metolachlor 51218452 x .................
----------------------------------------------------------------------------------------------------------------
Metribuzin 21087649 x .................
----------------------------------------------------------------------------------------------------------------
Myclobutanil 88671890 x .................
----------------------------------------------------------------------------------------------------------------
Norflurazon 27314132 x .................
----------------------------------------------------------------------------------------------------------------
o-Phenylphenol 90437 x .................
----------------------------------------------------------------------------------------------------------------
Oxamyl 23135220 x .................
----------------------------------------------------------------------------------------------------------------
Permethrin 52645531 x .................
----------------------------------------------------------------------------------------------------------------
Phosmet 732116 x .................
----------------------------------------------------------------------------------------------------------------
Piperonyl butoxide 51036 x .................
----------------------------------------------------------------------------------------------------------------
Propachlor 1918167 x .................
----------------------------------------------------------------------------------------------------------------
Propargite 2312358 x .................
----------------------------------------------------------------------------------------------------------------
[[Page 17585]]
Propiconazole 60207901 x .................
----------------------------------------------------------------------------------------------------------------
Propyzamide 23950585 x .................
----------------------------------------------------------------------------------------------------------------
Pyridine, 2-(1-methyl-2-(4-phenoxyphenoxy)ethoxy)- 95737681 x .................
----------------------------------------------------------------------------------------------------------------
Quintozene 82688 x .................
----------------------------------------------------------------------------------------------------------------
Resmethrin 10453868 x .................
----------------------------------------------------------------------------------------------------------------
Simazine 122349 x .................
----------------------------------------------------------------------------------------------------------------
Tebuconazole 107534963 x .................
----------------------------------------------------------------------------------------------------------------
Toluene 108883 x
----------------------------------------------------------------------------------------------------------------
Triadimefon 43121433 x .................
----------------------------------------------------------------------------------------------------------------
Trifluralin 1582098 x .................
----------------------------------------------------------------------------------------------------------------
VI. References
These references are available in the docket as identified under
ADDRESSES, under Docket ID No. EPA-HQ-OPPT-2004-0109, which is the
docket for the chemicals selected for the initial round of screening
under the EDSP. In addition, the first document referenced is available
in Docket ID No. EPA-HQ-OPPT-2002-0066, which is the docket used for
the proposed chemical selection approach described in the Federal
Register notice of December 30, 2002 (67 FR 79611) (FRL-7286-6).
1. U.S. EPA. Endocrine Disruptor Screening and Testing Advisory
Committee Final Report. August 1998. Available at: http:// www.epa.gov/
scipoly/oscpendo/edspoverview/finalrpt.htm. (Document ID No. EPA-HQ-
OPPT-2002-0066-0003).
2. U.S. EPA. ``Reponse to Comments on the Draft List of Initial
Pesticide Active Ingredients and Pesticide Inert Ingredients to be
Screened under the Federal Food, Drug, and Cosmetic Act.'' August 2008.
Available at: http://www.epa.gov/scipoly/oscpendo/pubs/
prioritysetting/. (Docket ID No. EPA-HQ-OPPT-2004-0109).
List of Subjects
Environmental protection, Chemicals, Endocrine disruptors,
Pesticides.
Dated: April 3, 2009.
James Jones,
Acting Assistant Administrator, Office of Prevention, Pesticides and
Toxic Substances.
[FR Doc. E9-8709 Filed 4-14-09; 8:45 am]
BILLING CODE 6560-50-S