[Federal Register Volume 75, Number 200 (Monday, October 18, 2010)]
[Notices]
[Pages 63840-63841]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2010-26153]
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DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Institutes of Health
Government-Owned Inventions; Availability for Licensing
AGENCY: National Institutes of Health, Public Health Service, HHS.
ACTION: Notice.
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SUMMARY: The inventions listed below are owned by an agency of the U.S.
Government and are available for licensing in the U.S. in accordance
with 35 U.S.C. 207 to achieve expeditious commercialization of results
of federally-funded research and development. Foreign patent
applications are filed on selected inventions to extend market coverage
for companies and may also be available for licensing.
ADDRESSES: Licensing information and copies of the U.S. patent
applications listed below may be obtained by writing to the indicated
licensing contact at the Office of Technology Transfer, National
Institutes of Health, 6011 Executive Boulevard, Suite 325, Rockville,
Maryland 20852-3804; telephone: 301/496-7057; fax: 301/402-0220. A
signed Confidential Disclosure Agreement will be required to receive
copies of the patent applications.
Prevention and Treatment of Herpes Virus Infection by Inhibition of the
JMJD2 Family of Histone Demethylases
Description of Invention: Investigators at the NIH have discovered
a potential means for preventing or treating a herpes virus infection
by inhibiting the activity of the host cell's histone demethylases.
When herpesviruses enter a cell, they are inactivated by cellular
defense mechanisms that wrap the viral genome in repressive chromatin
structures. In order for viral replication to progress, the host's own
histone demethylases are recruited to the viral genome to reverse this
repression. In a preceding invention, the laboratory disclosed that
viral replication and reactivation can be significantly reduced through
inhibition of the histone demethylase LSD1 using Mono-Amino Oxidase
Inhibitors (MAOIs); drugs that are in clinical use. The current
invention further discloses that inhibition of a second set of histone
demethylases (JMJD2 family) using a specific JMJD2 inhibitor,
dimethyloxaloylglycine (DMOG), also results in significant repression
of herpes viral replication.
Either alone or in combination, small molecule inhibition of LSD1
and the JMJD2 family present novel approaches for preventing herpes
virus infection and halting viral reactivation that can lead to a
disease that ranges from mild core sores to herpesvirus keratitis and
life-threatening encephalitis. Additionally, chromatin-mediated
repression of viral genomes and the requirement to de-repress these
genomes for productive infection appears to be general to
herpesviruses. Therefore, this treatment could also be applicable to
chicken pox, shingles, CMV disease, mononucleosis, and Kaposi's
sarcoma.
Applications: Prevention or treatment of infection by herpes
simplex virus and other diseases caused by herpesviruses (i.e. Epstein-
Barr virus, cytomegalovirus, varicella zoster, and Kaposi's sarcoma-
associated herpesvirus).
Advantage: Inhibition of histone demethylases provides an
alternative pathway for repressing herpes virus infection as compared
to purine analog antivirals. While purine analogs are the most widely
prescribed treatment for herpes infection, drug resistance is
prevalent. Additionally, inhibition of histone demethylases results in
no expression of viral gene products; in contrast to DNA replication
inhibitors.
Development Status:
Early-stage development
Pre-clinical data available for mice
Further pre-clinical and clinical development is needed
Market:
Genital herpes can result from infection with either HSV
type 2 or type 1, mainly by HSV type 2 in the U.S., which typically
causes more recurrent and severe manifestations of the disease.
According to the Centers for Disease Control and
Prevention, nationwide, 16.2%, or about one out of six, people 14 to 49
years of age have genital HSV-2 infection.
HSV keratitis is the most frequent cause of corneal
blindness in the United States.
Inventors: Thomas Kristie et al. (NIAID)
Publications: None related to this invention available at this
time.
Patent Status: U.S. Provisional Application No. 61/366,563 filed 22
Jul 2010 (HHS Reference No. E-184-2010/0-US-01).
Related Technologies: ``Use of Mono-Amine Oxidase Inhibitors to
Prevent Herpes Virus Infections and Reactivation from Latency''--HHS
Reference No. E-275-2008/2-PCT-02.
Licensing Status: Available for licensing.
Licensing Contacts:
Eric W. Odom, PhD; 301-435-5009; [email protected].
Susan O. Ano, PhD; 301-435-5515; [email protected].
Collaborative Research Opportunity: The NIAID Laboratory of Viral
Diseases is seeking statements of capability or interest from parties
interested in collaborative research to further develop, evaluate, or
commercialize prevention and treatment of viral diseases. Please
contact Thomas Kristie, PhD at 301.496.3854 or [email protected]
for more information.
Treatment of Inflammatory Bowel Disease (IBD) Using IL-13 Modulators
and Inhibitors
Description of Invention: Ulcerative colitis (UC), a chronic
inflammatory disease of the colorectum, affects approximately 400,000
people in the United States. The cause of UC is not known, although an
abnormal immunological response to bacterial antigens in the gut
microflora is thought to be involved. Available for licensing are broad
claims covering (1) treatments preventing the inflammatory response of
colitis by modulating IL-13 and Natural Killer T cell (NKT) activity
and (2) methods for screening for therapeutic compounds effective for
colitis. NIH scientists and their collaborators have used a mouse model
of experimental colitis (oxazolone colitis, OC) to show that IL-13, a
Th2 cytokine, is a significant pathologic factor in OC and that
neutralizing IL-13 in these animals effectively prevents colitis.
Inflammation in this mouse model has also been shown to be effectively
blocked by neutralizing IL-13 or by inhibiting the activation of NK-T
cells through CD1.
Oxazolone colitis (OC) is a colitis induced by intrarectal
administration of a relatively low dose of the haptenating agent
oxazolone subsequent to skin sensitization with oxazolone. A highly
reproducible and chronic colonic inflammation is obtained that is
histologically similar to human ulcerative colitis. Studies show that
NKT cells, rather than conventional CD4+T cells, mediate oxazolone
colitis,
[[Page 63841]]
are the source of IL-13, and are activated by CD1 expressing intestinal
epithelial cells. Tissue removed from UC patients were also shown to
contain increased numbers of nonclassical NKT cells that produce
markedly increased amounts of IL-13. In addition, these NKT cells are
cytotoxic for epithelial cells, supporting the concept that epithelial
damage is a key factor in UC.
Applications: Development of IL-13 and CD1 based therapeutics to
treat or prevent ulcerative colitis.
Development Status: Small animal model studies.
Inventors: Warren Strober, Ivan Fuss, Frank Heller, Richard
Blumberg (NIAID).
Related Publications:
1. IJ Fuss et al. Nonclassical CD1d-restricted NK T cells that
produce IL-13 characterize an atypical Th2 response in ulcerative
colitis. J Clin Invest. 2004 May;113(10):1490-1497. [PubMed: 15146247].
2. F Heller et al. Oxazolone colitis, a Th2 colitis model
resembling ulcerative colitis, is mediated by IL-13-producing NK-T
cells. Immunity 2002 Nov;17(5):629-638. [PubMed: 12433369].
Patent Status:
U.S. Patent No. 7,666,411 issued 23 Feb 2010 (HHS
Reference No. E-131-2002/0-US-02).
U.S. Patent Application No. 12/709,029 filed 19 Feb 2010
(HHS Reference No. E-131-2002/0-US-10).
International patent/patent application filings.
Related Technologies: Related IBD technologies also available for
licensing include IL-13 mutant and chimeric molecules (HHS Reference
No. E-003-2005/0) and NF-kappa B decoy oligonucleotides (HHS Reference
No. E-108-2005/0).
Licensing Status: Available for licensing.
Licensing Contact: Sury Vepa, PhD, J.D.; 301-435-5020;
[email protected].
Dated: October 12, 2010.
Richard U. Rodriguez,
Director, Division of Technology Development and Transfer, Office of
Technology Transfer, National Institutes of Health.
[FR Doc. 2010-26153 Filed 10-15-10; 8:45 am]
BILLING CODE 4140-01-P