[Code of Federal Regulations]
[Title 21, Volume 7]
[Revised as of April 1, 2001]
From the U.S. Government Printing Office via GPO Access
[CITE: 21CFR700.18]

[Page 128-129]
 
                        TITLE 21--FOOD AND DRUGS
 
          DEPARTMENT OF HEALTH AND HUMAN SERVICES--(Continued)
 
PART 700--GENERAL--Table of Contents
 
         Subpart B--Requirements for Specific Cosmetic Products
 
Sec. 700.18  Use of chloroform as an ingredient in cosmetic products.

    (a) Chloroform has been used as an ingredient in cosmetic products. 
Recent information has become available associating chloroform with 
carcinogenic effects in animals. Studies conducted by the National 
Cancer Institute have demonstrated that the oral administration of 
chloroform to mice and rats induced hepatocellular carcinomas (liver 
cancer) in mice and renal tumors in male rats. Scientific literature 
indicates that chloroform is absorbed from the gastrointestinal tract, 
through the respiratory system, and through the skin. The Commissioner 
concludes that, on the basis of

[[Page 129]]

these findings, chloroform is a deleterious substance which may render 
injurious to users any cosmetic product that contains chloroform as an 
ingredient.
    (b) Any cosmetic product containing chloroform as an ingredient is 
adulterated and is subject to regulatory action under sections 301 and 
601(a) of the Federal Food, Drug, and Cosmetic Act. Any cosmetic product 
containing chloroform in residual amounts from its use as a processing 
solvent during manufacture, or as a byproduct from the synthesis of an 
ingredient, is not, for the purpose of this section, considered to 
contain chloroform as an ingredient.

[41 FR 26845, June 29, 1976]