[Code of Federal Regulations] [Title 21 Volume 5] [Revised as of April 1, 2003] From the U.S. Government Printing Office via GPO Access [CITE: 21CFR315.3] [Page 165-166] TITLE 21--FOOD AND DRUGS CHAPTER I--FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) PART 315--DIAGNOSTIC RADIOPHARMACEUTICALS--Table of Contents Sec. 315.3 General factors relevant to safety and effectiveness. FDA's determination of the safety and effectiveness of a diagnostic radiopharmaceutical includes consideration of the following: (a) The proposed use of the diagnostic radiopharmaceutical in the practice of medicine, (b) The pharmacological and toxicological activity of the diagnostic [[Page 166]] radiopharmaceutical (including any carrier or ligand component of the diagnostic radiopharmaceutical), and (c) The estimated absorbed radiation dose of the diagnostic radiopharmaceutical.