[Code of Federal Regulations]
[Title 21, Volume 6]
[Revised as of January 1, 2003]
From the U.S. Government Printing Office via GPO Access
[CITE: 21CFR522.840]

[Page 237]
 
                        TITLE 21--FOOD AND DRUGS
 
CHAPTER I--FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN 
                          SERVICES (CONTINUED)
 
PART 522--IMPLANTATION OR INJECTABLE DOSAGE FORM NEW ANIMAL DRUGS--Table of Contents
 
Sec.  522.840  Estradiol.

    (a) Specifications. Each silicone rubber implant contains 25.7 or 
43.9 milligrams of estradiol.
    (b) Sponsor. See No. 021641 in Sec.  510.600(c) of this chapter.
    (c) Conditions of use. It is used for implantation in steers and 
heifers as follows:
    (1) Amount. Insert one 25.7-milligram implant every 200 days; insert 
one 43.9-milligram implant every 400 days.
    (2) Indications for use. For increased rate of weight gain in 
suckling and pastured growing steers; for improved feed efficiency and 
increased rate of weight gain in confined steers and heifers.
    (3) Limitations. For subcutaneous ear implantation in steers and 
heifers only. A second implant may be used if desired. No additional 
effectiveness may be expected from reimplanting in less than 200 days 
for the 25.7-milligram implant or 400 days for the 43.9 milligram 
implant. Increased sexual activity (bulling, riding, and excitability) 
has been reported in implanted animals.

[51 FR 22276, June 19, 1986, as amended at 57 FR 41861, Sept. 14, 1992; 
66 FR 56035, Nov. 6, 2001]