[Code of Federal Regulations]
[Title 21, Volume 6]
[Revised as of January 1, 2003]
From the U.S. Government Printing Office via GPO Access
[CITE: 21CFR558.185]

[Page 397-398]
 
                        TITLE 21--FOOD AND DRUGS
 
CHAPTER I--FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN 
                          SERVICES (CONTINUED)
 
PART 558--NEW ANIMAL DRUGS FOR USE IN ANIMAL FEEDS--Table of Contents
 
      Subpart B--Specific New Animal Drugs for Use in Animal Feeds
 
Sec.  558.185  Coumaphos.

    (a) Approvals. Type A medicated articles:
    (1) [Reserved]
    (2) 1.12 and 11.2 percent to 017800 in Sec.  510.600(c) of this 
chapter for use as in paragraph (d)(1)(ii) of this section.
    (b) Special considerations. Adequate directions and warnings for use 
must be given and shall include a statement that coumaphos is a 
cholinesterase inhibitor and that animals being treated with coumaphos 
should not be exposed during or within a few days before or after 
treatment to any other cholinesterase-inhibiting drugs, insecticides, 
pesticides, or chemicals.
    (c) Related tolerances. See 40 CFR 180.189.
    (d) Conditions of use. It is used as follows:
    (1) Beef and dairy cattle--(i) Amount. Coumaphos 0.00012 lb. (0.054 
gram) per 100 lb. body weight per day.
    (a) Indications for use. As an aid in the reduction of fecal 
breeding flies through control of fly larvae.
    (b) Limitations. Feed for the duration of fly season in a Type C 
feed containing 0.0033 percent or in a feed Type B feed containing not 
over 0.0066 percent coumaphos; do not feed to animals less than 3 months 
old; not for use in pelleted feeds.
    (ii) Amount. Coumaphos, 0.0002 lb. (0.091 gram) per 100 lb. body 
weight per day.

[[Page 398]]

    (a) Indications for use. Control of gastrointestinal roundworms 
(Haemonchus spp., Ostertagia spp., Cooperia spp., Nematodirus spp., 
Trichostrongylus spp.).
    (b) Limitations. Feed 0.0002 lb. (0.091 gram) per 100 lb. body 
weight per day for 6 consecutive days in the normal grain ration to 
which the animals are accustomed but not in rations containing more than 
0.1 percent coumaphos; do not feed to animals less than 3 months old; do 
not feed to sick animals or animals under stress, such as those just 
shipped, dehorned, castrated, or weaned within the last 3 weeks; do not 
feed in conjunction with oral drenches or with feeds containing 
phenothiazine. Should conditions warrant, repeat treatment at 30-day 
intervals.
    (2) Laying chickens--(i) Amount. Coumaphos 27.2 grams per ton (0.003 
percent).
    (ii) Indications for use. For control of capillary worm (Capillaria 
obsignata) and as an aid in control of common round worm (Ascaridia 
galli) and cecal worm (Heterakis gallinae).
    (iii) Limitations. In Type C feed; administer continuously as the 
total feed ration for 14 days; when reinfection occurs, treatment may be 
repeated but not sooner than 3 weeks after the end of the previous 
treatment; do not feed to chickens within 10 days of vaccination or 
other conditions of stress; treatment of colored breeds of commercial 
layers should be avoided while in production since these breeds appear 
to be more sensitive to coumaphos than white breeds; as sole medication; 
medications in general should be avoided while birds are approaching 
peak production; such interruption of normal feeding practices may upset 
the flock and lower egg production; diagnosis by competent personnel is 
essential; flock condition and production records should be carefully 
evaluated prior to treatment.
    (3) Replacement pullets--(i) Amount. Coumaphos 36.3 grams per ton 
(0.004 percent).
    (ii) Indications for use. For control of capillary worm (Capillaria 
obsignata) and as an aid in control of common roundworm (Ascaridia 
galli) and cecal worm (Heterakis gallinae).
    (iii) Limitations. In Type C feed; administer before the onset of 
production; diagnosis by competent personnel is essential; administer 
continuously as total feed ration for from 10 to 14 days; do not feed to 
chickens under 8 weeks of age nor within 10 days of vaccination or other 
conditions of stress; if birds are maintained on contaminated litter or 
exposed to infected birds, a second 10 to 14 day treatment is 
recommended but not sooner than 3 weeks after the end of the previous 
treatment; as sole medication; if reinfection occurs after production 
begins, repeat treatment as recommended for laying flocks.

[40 FR 13959, Mar. 27, 1975, as amended at 42 FR 1463, Jan. 7, 1977; 51 
FR 7397, Mar. 3, 1986; 52 FR 2684, Jan. 26, 1987; 61 FR 34729, July 3, 
1996]