[Code of Federal Regulations] [Title 45, Volume 3] [Revised as of October 1, 2005] From the U.S. Government Printing Office via GPO Access [CITE: 45CFR690.120] [Page 264-265] TITLE 45--PUBLIC WELFARE CHAPTER VI--NATIONAL SCIENCE FOUNDATION PART 690_PROTECTION OF HUMAN SUBJECTS--Table of Contents Sec. 690.120 Evaluation and disposition of applications and proposals for research to be conducted or supported by a Federal department or agency. The department or agency head will evaluate all applications and proposals involving human subjects submitted to the department or agency through such officers and employees of the department or agency and such experts and [[Page 265]] consultants as the department or agency head determines to be appropriate. This evaluation will take into consideration the risks to the subjects, the adequacy of protection against these risks, the potential benefits of the research to the subjects and others, and the importance of the knowledge gained or to be gained. (b) On the basis of this evaluation, the department or agency head may approve or disapprove the application or proposal, or enter into negotiations to develop an approvable one.