[Code of Federal Regulations] [Title 21, Volume 8] [Revised as of April 1, 2006] From the U.S. Government Printing Office via GPO Access [CITE: 21CFR1271] [Page 726] TITLE 21--FOOD AND DRUGS CHAPTER I--FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) PART 1271_HUMAN CELLS, TISSUES, AND CELLULAR AND TISSUE-BASED PRODUCTS --Table of Contents Subpart B_Procedures for Registration and Listing Sec. 1271.21 When do I register, submit an HCT/P list, and submit updates? (a) You must register and submit a list of every HCT/P that your establishment manufactures within 5 days after beginning operations or within 30 days of the effective date of this regulation, whichever is later. (b) You must update your establishment registration annually in December, except as required by Sec. 1271.26. You may accomplish your annual registration in conjunction with updating your HCT/P list under paragraph (c) of this section. (c)(i) If no change described in Sec. 1271.25(c) has occurred since you previously submitted an HCT/P list, you are not required to update your listing. (ii) If a change described in Sec. 1271.25(c) has occurred, you must update your HCT/P listing with the new information: (a) At the time of the change, or (b) Each June or December, whichever month occurs first after the change. [69 FR 68681, Nov. 24, 2004]