[Code of Federal Regulations]

[Title 40, Volume 23]

[Revised as of July 1, 2006]

From the U.S. Government Printing Office via GPO Access

[CITE: 40CFR180.35]



[Page 324]

 

                   TITLE 40--PROTECTION OF ENVIRONMENT

 

         CHAPTER I--ENVIRONMENTAL PROTECTION AGENCY (CONTINUED)

 

PART 180_TOLERANCES AND EXEMPTIONS FROM TOLERANCES FOR PESTICIDE 

CHEMICALS IN FOOD--Table of Contents

 

                    Subpart B_Procedural Regulations

 

Sec.  180.35  Tests for potentiation.



    Experiments have shown that certain cholinesterase-inhibiting 

pesticides when fed together to test animals are more toxic than the sum 

of their individual toxicities when fed separately. One substance 

potentiates the toxicity of the other. Important toxicological 

interactions also have been observed between pesticides and other 

substances. Wherever there is reason to believe that a pesticide 

chemical for which a tolerance is proposed may interact with other 

pesticide chemicals or other substances to which man is exposed, it may 

be necessary to require special experimental data regarding potentiation 

capacities to evaluate the safety of the proposed tolerance. This 

necessarily will be determined on a case-by-case basis.