[Code of Federal Regulations]
[Title 21, Volume 3]
[Revised as of January 1, 2007]
From the U.S. Government Printing Office via GPO Access
[CITE: 21CFR189.180]

[Page 596]
 
                        TITLE 21--FOOD AND DRUGS
 
CHAPTER I--FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN 
                          SERVICES (CONTINUED)
 
PART 189_SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD--Table of Contents
 
Subpart C_Substances Generally Prohibited From Direct Addition or Use as 
                               Human Food
 
Sec.  189.180  Safrole.

    (a) Safrole is the chemical 4-allyl-1,2-methylenedioxy-benzene, 
C10H10O2. It is a natural constituent 
of the sassafras plant. Oil of sassafras is about 80 percent safrole. 
Isosafrole and dihydrosafrole are derivatives of safrole, and have been 
used as flavoring compounds.
    (b) Food containing any added safrole, oil of sassafras, isosafrole, 
or dihydrosafrole, as such, or food containing any safrole, oil of 
sassafras, isosafrole, or dihydrosafrole, e.g., sassafras bark, which is 
intended solely or primarily as a vehicle for imparting such substances 
to another food, e.g., sassafras tea, is deemed to be adulterated in 
violation of the act based upon an order published in the Federal 
Register of December 3, 1960 (25 FR 12412).
    (c) The analytical method used for detecting safrole, isosafrole and 
dihydrosafrole is in the ``Journal of the Association of Official 
Analytical Chemists,'' Volume 54 (Number 4), pages 900 to 902, July 
1971, which is incorporated by reference. Copies are available from the 
Division of Food and Color Additives, Center for Food Safety and Applied 
Nutrition (HFS-200), Food and Drug Administration, 5100 Paint Branch 
Pkwy., College Park, MD 20740, or available for inspection at the 
National Archives and Records Administration (NARA). For information on 
the availability of this material at NARA, call 202-741-6030, or go to: 
http://www.archives.gov/federal--register/code--of--federal--
regulations/ibr--locations.html.

[42 FR 14659, Mar. 15, 1977, as amended at 42 FR 56729, Oct. 28, 1977; 
47 FR 11855, Mar. 19, 1982; 54 FR 24900, June 12, 1989]