[Code of Federal Regulations] [Title 21, Volume 5] [Revised as of April 1, 2007] From the U.S. Government Printing Office via GPO Access [CITE: 21CFR315.3] [Page 171] TITLE 21--FOOD AND DRUGS CHAPTER I--FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) PART 315_DIAGNOSTIC RADIOPHARMACEUTICALS--Table of Contents Sec. 315.3 General factors relevant to safety and effectiveness. FDA's determination of the safety and effectiveness of a diagnostic radiopharmaceutical includes consideration of the following: (a) The proposed use of the diagnostic radiopharmaceutical in the practice of medicine, (b) The pharmacological and toxicological activity of the diagnostic radiopharmaceutical (including any carrier or ligand component of the diagnostic radiopharmaceutical), and (c) The estimated absorbed radiation dose of the diagnostic radiopharmaceutical. [[Page 172]]