[Code of Federal Regulations] [Title 21, Volume 5] [Revised as of April 1, 2007] From the U.S. Government Printing Office via GPO Access [CITE: 21CFR316.23] [Page 180] TITLE 21--FOOD AND DRUGS CHAPTER I--FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) PART 316_ORPHAN DRUGS--Table of Contents Subpart C_Designation of an Orphan Drug Sec. 316.23 Timing of requests for orphan-drug designation; designation of already approved drugs. (a) A sponsor may request orphan-drug designation at any time in the drug development process prior to the submission of a marketing application for the drug product for the orphan indication. (b) A sponsor may request orphan-drug designation of an already approved drug product for an unapproved use without regard to whether the prior marketing approval was for an orphan-drug indication. [[Page 181]]