[Code of Federal Regulations] [Title 40, Volume 23] [Revised as of July 1, 2007] From the U.S. Government Printing Office via GPO Access [CITE: 40CFR158.740] [Page 127-138] TITLE 40--PROTECTION OF ENVIRONMENT CHAPTER I--ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PART 158_DATA REQUIREMENTS FOR REGISTRATION--Table of Contents Subpart D_Data Requirement Tables Sec. 158.740 Microbial pesticides--Product analysis data requirements. (a) Microbial pesticides product analysis data requirements--(1) Table. Sections 158.50 and 158.100 through 158.102 describe how to use this table to determine the microbial pesticides--product analysis data requirements and the substance to be tested. ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ General use patterns Test substance ------------------------------------------------------------------------------------------------------------------------------------------- Guidelines Kind of data required (2) Notes Terrestrial Aquatic Greenhouse reference ---------------------------------------------------------------------- Forestry Domestic Indoor Data to support Data to support No. Food crop Nonfood Food crop Nonfood Food crop Nonfood outdoor MP EP ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ Product identity manufacturing ......... [R] [R] [R] [R] [R] [R] [R] [R] [R] MP.............. EP*............. 151-20 process. (i) [R] [R] [R] [R] [R] [R] [R] [R] [R] MP and TGAI..... EP* and TGAI.... 151-21 Discussion of formation of (ii) [R] [R] [R] [R] [R] [R] [R] [R] [R] MP and TGAI..... EP* and TGAI.... 151-22 unintentional ingredients. [[Page 128]] Analysis of samples........... (iii) [CR] [CR] [CR] [CR] [CR] [CR] [CR] [CR] [CR] MP and TGAI..... EP* and TGAI.... 151-23 Certification of limits....... ......... [R] R [R] R [R] R R R R MP.............. EP*............. 151-25 Analytical methods............ ......... R R R R R R R R R MP.............. EP*............. 151-25 Physical and chemical ......... [R] [R] [R] [R] [R] [R] [R] [R] [R] MP and TGAI..... EP* and TGAI.... 151-26 properties. Submittal of samples.......... (iv) [CR] [CR] [CR] [CR] [CR] [CR] [CR] [CR] [CR] MP and TGAI, PAI EP* TGAI and PAI 151-27 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ Key: R=Required; CR=Conditionally required; MP=Manufacturing-use product: EP*=End-use product (asterisk identifies those data requirements that end-use applicants (i.e., ``formulators'') must satisfy, provided that their active ingredient(s) is (are) purchased from a registered source); TGAI=Technical grade of the active ingredient; [ ]=Brackets (i.e., [R], [CR]) indicate data requirements that apply when an experimental use permit is being sought. (2) Notes. The following notes are referenced in column two of the table contained in paragraph (a)(1) of this section. (i) If an experimental use permit is being sought, a schematic diagram and/or description of the manufacturing process will suffice if the pesticide is not already under scale production. (ii) If the product is not already under full scale production and an experimental use permit is being sought, a discussion of unintentional ingredients shall be submitted to the extent this information is available. (iii) Required to support registration of each manufacturing-use product and end use products produced by an integrated formulation system. Data on other end use products will be required on a case-by-case basis. For pesticide in the production stage, a rudimentary product analytical method and data will suffice to support an experimental use permit. AAA(iv) Routinely required for products produced by an integrated formulation system. Required on a case-by-case basis for other products or materials. (b) Microbial pesticides-residue data requirements--(1) Table. Sections 158.50 and 158.100 through 158.102 describe how to use this table to determine the microbial pesticides-residue data requirements and the substances to be tested. ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ General use patterns Test substance ------------------------------------------------------------------------------------------------------------------------------------------- Guidelines Kind of data required (2) Notes Terrestrial Aquatic Greenhouse reference ---------------------------------------------------------------------- Forestry Domestic Indoor Data to support Data to support No. Food crop Nonfood Food crop Nonfood Food crop Nonfood outdoor MP EP ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ Residue data.................. (i) [CR] [CR] [CR] [CR] [CR] [CR] [CR] [CR] [CR] ................ ................ 153-4 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ Key: CR=Conditionally required data; EP=End-use product; MP=Manufacturing-use product; [ ]=Brackets (i.e., [CR]) indicate data requirements that apply when an experimental use permit is being sought. (2) Notes. The following notes are referenced in column two of the table contained in paragraph (b)(1) of this section. (i) Residue data requirements shall apply to microbial pesticides when Tier II or Tier III toxicology data are required, as specified for microbial pesticides in (c)(1) of this section. (ii) [Reserved) (c) Microbial pesticides-toxicology data requirements--(1) Table. Sections 158.50 and 158.100 through 158.102 describe how to use this table to determine the microbial pesticides-toxicology data requirements and the substances to be tested. [[Page 129]] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ General use patterns Test substance ------------------------------------------------------------------------------------------------------------------------------------------- Guidelines Kind of data required (2) Notes Terrestrial Aquatic Greenhouse reference ---------------------------------------------------------------------- Forestry Domestic Indoor Data to support Data to support No. Food crop Nonfood Food crop Nonfood Food crop Nonfood outdoor use MP EP ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ Tier I: Acute oral................ ......... [R] [R] [R] [R] [R] [R] [R] [R] [R] MP and TGAI..... EP* or EP* 152-30 dilution and TGAI. Acute dermal.............. ......... [R] [R] [R] [R] [R] [R] [R] [R] [R] MP and TGAI..... EP* or EP 152-31 dilution and TGAI. Acute inhalation.......... (i) [R] [R] [R] [R] [R] [R] [R] [R] [R] MP and TGAI..... EP* or EP 152-32 Dilution* and TGAI. I.V., I.C., I.P. injection (ii) [R] [R] [R] [R] [R] [R] [R] [R] [R] TGAI............ TGAI............ 152-33 Primary dermal............ ......... [R] [R] [R] [R] [R] [R] [R] [R] [R] MP.............. EP*............. 152-34 Primary eye............... ......... [R] [R] [R] [R] [R] [R] [R] [R] [R] MP.............. EP*............. 152-35 Hypersensitivity study.... (iii) R R R R R R R R R MP.............. EP*............. 152-36 Hypersensitivity incidents (iv) CR CR CR CR CR CR CR CR CR ................ ................ 152-37 Immune response........... ......... [R] R [R] R [R] R R R R TGAI............ TGAI............ 152-38 Tissue culture............ (v) [R] R [R] R [R] R R R R TGAI............ TGAI............ 152-39 Tier II: Acute oral................ (vi) CR CR CR CR CR CR CR CR CR MP.............. EP*............. 152-40 Acute inhalation.......... (vii) CR CR CR CR CR CR CR CR CR MP.............. EP*............. 152-41 Subchronic oral........... (viii) CR CR CR CR CR CR CR CR CR TGAI............ TGAI............ 152-42 Acute I.P., I.C........... (ix) CR CR CR CR CR CR CR CR CR TGAI............ TGAI............ 152-43 Primary dermal............ (x) CR CR CR CR CR CR CR CR CR ................ EP*............. 152-44 Primary eye............... (xi) CR CR CR CR CR CR CR CR CR ................ EP*............. 152-45 Immune response........... (xii) CR CR CR CR CR CR CR CR CR TGAI............ TGAI............ 152-46 Teratogenicity............ (xiii) CR CR CR CR CR CR CR CR CR TGAI............ TGAI............ 152-47 Virulence enhancement..... (xiv) CR CR CR CR CR CR CR CR CR TGAI............ TGAI............ 152-48 Mammalian mutagenicity.... (xv) CR CR CR CR CR CR CR CR CR TGAI............ TGAI............ 152-49 Tier III: Chronic feeding........... (xvi) CR .......... CR .......... CR ......... ......... ......... CR TGAI............ TGAI............ 152-50 Oncogenicity.............. (xvii) CR .......... CR .......... CR ......... ......... ......... CR TGAI............ TGAI............ 151-51 Mutagenicity.............. (xviii) CR CR CR CR CR CR CR CR CR TGAI............ TGAI............ 152-52 Teratogenicity............ (xix) CR CR CR CR CR CR CR CR CR TGAI............ TGAI............ 152-53 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ Key: R=Required; CR=Conditionally required; MP=Manufacturing-use product; EP*=End use product (asterisk identifies those data requirements that end-use applicants (i.e., ``formulators'') must satisfy, provided that their active ingredient(s) is (are) purchased from a registered source); TGAI=Technical Grade of the Active Ingredient; [ ]=Brackets (i.e., [R], [CR]) indicate data requirements that apply when an experimental use permit is being sought. (2) Notes. The following notes are referenced in column two of the table contained in paragraph (c)(1) of this section. (i) Required if 20 percent or more of the aerodynamic equivalent of the product (as registered or under conditions of use) is composed of particulates less than 10 microns in diameter. (ii) Data required for products as follows: (A) Intravenous (``IV'') infectivity study for bacterial, and viral agents; (B) Intracerebral (``IC'') infectivity study for viral and protozoan agents; and [[Page 130]] (C) Intraperitoneal (``IP'') infectivity study for fungal and protozoan agents. (iii) Required if commonly recognized use practices will result in repeated human contact by inhalation or dermal routes. (iv) Hypersensitivity incidents must be reported, if they occur. (v) Data required for products whose active ingredient is a virus. (vi) Required if survival, replication, infectivity, toxicity, or persistence of the microbial agent (virus or protozoa) is observed in the test animals treated in the Tier I acute oral infectivity tests or the intraperitoneal or intracerebral injection test for protozoa. (vii) Required if survival, replication, infectivity, toxicity, or persistence of the microbial agent (virus or protozoa) is observed in the test animals treated in the comparable Tier I acute inhalation tests. (viii) Required if there is evidence of survival, replication, infectivity, or persistence of the protozoan agent in the Tier I oral infectivity test. (ix) Required if in Tier I acute oral infectivity testing, Tier I dermal toxicity/infectivity testing, or Tier I intraperitoneal or intracerebral injection testing, the test microorganism (bacteria, fungi, or protozoa) survived for more than 2 weeks, caused toxic effects, or caused a severe illness response in an experimental animal as evidenced by irreversible gross pathology, severe weight loss, toxemia, or death. (x) Required if infectivity or if marked edema or broad erythema was observed in the Tier I dermal irritation study. (xi) Required if infectivity or if severe ocular lesions are observed in the Tier I primary eye irritation study. (xii) Required if results of the Tier I immune response test indicate abnormalities. (xiii) Required when Tier I tests on viral agents show replication of the virus in mammalian hosts and significant damage to mammalian cells. (xiv) Required when Tier I infectivity tests on bacteria or fungi indicate prolonged survival (including presence of viable microbial agents in test animal excreta) and/or multiplication (infectivity) of the bacteria or fungal agent, respectively. (xv) Required if any of the following criteria are met: (A) Acute infectivity tests are positive in Tier I studies. (B) Adverse effects are observed in immune response studies. (C) Positive results are obtained in tissue culture tests with viral agents. (xvi) Required when the potential for chronic adverse effects (e.g., replication or persistence of viral or subviral constituents, protozoans, fungi, or bacteria) are demonstrated by any of the Tier II tests (except primary dermal, primary ocular, and mammalian mutagenicity tests). (xvii) Required when the potential for oncogenic effects is indicated (e.g., adverse cellular effects due to presence, replication, or persistence of viral or subviral constituents, or bacteria, fungi or protozoans; or mutagenic effects) by any of the Tier II tests except the primary dermal and primary ocular studies. (xviii) Required when the potential for mutagenic effects is indicated (e.g., adverse cellular effects due to presence, replication, or persistence of viral or subviral constituents, bacteria, fungi or protozoa) by any of the Tier II tests except primary dermal or primary ocular studies. (xix) Required when the potential for teratogenic effects is expected based on the presence of persistence of fungi, bacteria, viruses, or protozoa in mammalian species as a result of testing performed in Tier II, except primary dermal and primary ocular studies. (d) Microbial pesticides non-target organism and environmental expression data requirements--(1) Table. Sections 158.50 and 158.100 through 158.102 describe how to use this table to determine the microbial pesticides non-target organism and environmental expression data requirements and substances to be tested. ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ General use patterns Test substance ------------------------------------------------------------------------------------------------------------------------------------------- Guidelines Kind of data required (2) Notes Terrestrial Aquatic Greenhouse reference ---------------------------------------------------------------------- Forestry Domestic Indoor Data to support Data to support No. Food crop Nonfood Food crop Nonfood Food crop Nonfood outdoor use MP EP ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ Tier I: Avian oral................ (i), [R] [R] [R] [R] CR CR [R] [R] CR TGAI............ TGAI............ 154-16 (ii), (iii) Avian injection test...... (i), [R] [R] [R] [R] CR CR [R] [R] CR TGAI............ TGAI............ 154-17 (ii), (iii) Wild mammal testing....... (iv) CR CR CR CR ......... ......... CR CR ......... TGAI............ TGAI............ 154-18 Freshwater fish testing... (i) [R] [R] [R] [R] CR CR [R] CR CR TGAI............ TGAI............ 154-19 Freshwater aquatic (i) [R] [R] [R] [R] CR CR [R] CR CR TGAI............ TGAI............ 154-20 invertebrate testing. Estuarine and marine (v) CR CR CR CR ......... ......... CR CR ......... TGAI............ TGAI............ 154-2 animal testing. [[Page 131]] Nontarget plant studies... ......... [R] [R] [R] [R] ......... ......... [R] [R] CR TEP............. TEP............. 154-2 Nontarget insect testing.. ......... [R] [R] [R] [R] CR CR [R] [R] ......... TGAI............ TGAI............ 154-23 Honey bee testing......... ......... [R] [R] [R] [R] CR CR [R] [R] ......... TGAI............ TGAI............ 154-24 Tier II: Terrestrial environmental (vi) CR CR CR CR ......... ......... CR CR ......... TGAI or TEP..... TGAI or TEP..... 155-18 testing. Freshwater environmental (vii) CR CR CR CR ......... ......... CR CR ......... TGAI or TEP..... TGAI or TEP..... 155-19 expression tests. Marine or estuarine (xiii), CR CR CR CR ......... ......... CR CR ......... TGAI or TEP..... TGAI or TEP..... 155-20 environmental expression (ix) tests. Tier III: Terrestrial wildlife and (x) CR CR CR CR ......... ......... CR CR ......... TGAI or TEP..... TGAI or TEP..... 154-25 aquatic organism testing. Avian pathogenicity/ (xi) CR CR CR CR ......... ......... CR CR ......... TGAI............ TGAI............ 154-26 reproduction test. Definitive aquatic animal (xii) CR CR CR CR ......... ......... CR CR ......... TGAI............ TGAI............ 154-27 tests. Aquatic embryo larvae and (xiii) CR CR CR CR ......... ......... CR CR ......... TGAI............ TGAI............ 154-28 life cycle studies. Aquatic ecosystem test.... (xiv) CR CR CR CR ......... ......... CR CR ......... TGAI............ TGAI............ 154-29 Special aquatic tests ......... .......... .......... .......... .......... ......... ......... ......... ......... ......... ................ ................ 154-30 (reserved). Nontarget plant studies... (xv) CR CR CR CR ......... ......... CR CR ......... TGAI............ TEP............. 154-31 Tier IV: (xvi) Simulated and actual field (xiii) CR CR CR CR ......... ......... CR CR ......... TEP............. TEP............. 154-33 tests (birds, mammals). Simulated and actual field (xvii), CR CR CR CR ......... ......... CR CR ......... TEP............. TEP............. 154-34 tests (aquatic organisms). (xviii) Simulated and actual field ......... .......... .......... .......... .......... ......... ......... ......... ......... ......... ................ ................ 154-35 tests (insect predators, parasites) (reserved). Simulated and actual field ......... .......... .......... .......... .......... ......... ......... ......... ......... ......... ................ ................ 154-36 tests (insect pollinators) (reserved). ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ AAAKey: R=Required; CR=Conditionally required; [ ]=Brackets (i.e., [R], [CR]) indicates data requirements that apply to products for which an experimental use permit is being sought; MP=Manufacturing-use Product; TEP=Typical end-use product; TGAI=Technical grade of the active ingredient; EP=End-use product; PAI=``Pure'' active ingredient. AAA(2) Notes. The following notes are referenced in column two of the table contained in paragraph (d)(1) of this section. [[Page 132]] AAA(i) Tests for pesticides intended solely for indoor application will be required on a case-by-case basis, depending on use pattern, production volume, and other pertinent factors. AAA(ii) Preferable test species are: bobwhite quail or mallard for avian acute oral and avian dietary studies; rainbow trout for freshwater fish studies. AAA(iii) Data from either the avian acute oral or the avian injection study are required to support an experimental use permit. AAA(iv) Required on a case-by-case basis if results of tests required by paragraph (c)(1) of this section are inadequate or inappropriate for assessment of hazards to wild animals. AAA(v) Required when product is intended for direct application into the estuarine or marine environment or expected to enter this environment in significant concentrations because of expected use or mobility pattern. AAA(vi) Required when toxic or pathogenic effects are observed in any of the following Tier I tests for microbial pest control agents: AAA(A) Avian single dose oral toxicity and pathogenicity tests. AAA(B) Avian injection pathogenicity tests. AAA(C) Wild mammals toxicity and pathogenicity test. AAA(D) Plant studies--terrestrial. AAA(E) Honey bee toxicity/pathogenicity test. AAA(F) Testing for toxicity/pathogenicity to insect predators and parasites. AAA(vii) Required when toxic or pathogenic effects are observed in any of the following Tier I test for microbial pest control agents: AAA(A) Freshwater fish toxicity and pathogenicity testing. AAA(B) Freshwater aquatic invertebrate toxicity and pathogenicity test. AAA(C) Plant studies--aquatic. AAA(viii) Required if product is applied on land or in fresh water and toxic or pathogenic effects are observed in any of the following Tier I tests for microbial pest control agents: AAA(A) Estuarine and marine animal toxicity and pathogenicity test. AAA(B) Plant studies--estuarine or marine. AAA(ix) Required if product is applied in marine or estuarine environments and toxic or pathogenic effects are observed in any of the following Tier I tests: AAA(A) Avian single dose oral toxicity and pathogenicity test. AAA(B) Avian injection pathogenicity test. AAA(C) Estuarine and marine animal toxicity and pathogenicity test. AAA(x) Required when toxic effects on nontarget terrestrial wildlife or aquatic organisms are reported in one or more Tier I tests and results of Tier II tests indicate exposure of the mocrobial agent to the affected nontarget terrestrial wildlife or aquatic organisms. AAA(xi) Required when: AAA(A) Pathogenic effects are observed in Tier I avian tests at a level equal to the adjusted host equivalent amount. AAA(B) Chronic, carcinogenic, or teratogenic effects are reported in tests required by paragraph (c)(1) of this section for evaluating hazard to humans and domestic animals. AAA(C) Tier II Environmental expression testing indicates that exposure of terrestrial animals to the microbial agent is likely. AAA(xii) Required when product is intended for use in water or expected to be transported to water from the intended use site, and when pathogenicity or infectivity was observed in Tier I tests. AAA(xiii) Required when both of the following conditions are met: AAA(A) Pathogenic effects at actual or expected field residue exposure levels are reported in Tier III. AAA(B) The agency determines that quarantine methods will prevent the microbial pest control agent from contaminating areas adjacent to the test area. AAA(xiv) Required if, after an analysis of the microbial agent's properties, the individual use patterns, and the results of previous nontarget organism and environmental expression tests, it is determined that use of the microbial agent may result in adverse effects on the nontarget organisms in aquatic environments, including those of the water column and bottom sediments. When a microbial pest control agent is used in or is expected to transport to water from the intended use site, major considerations for requiring these infectivity tests include, but are not limited to: AAA(A) Infectivity or pathogenicity demonstrated in previous testing. AAA(B) Viability of the microorganism in natural waters as demonstrated in Tier II tests. AAA(xv) Required if the product is transported from the site of application by air, soil, or water or transmission by other animals. The extent of movement will be determined by the environmental expression tests in Tier II. AAA(xvi) The Agency expects that Tier IV requirements would be imposed retrospectively--after product registration as post registration monitoring, since it is unlikely a registrant would pursue registration of a microbial agent posing potential hazards such that testing beyond Tier III is required. AAA(xvii) Short term simulated or actual field studies are required when it is determined that the product is likely to cause adverse short-term or acute effects, based on consideration of available laboratory data, use patterns, and exposure rates. AAA(xviii) Data from a long-term simulated field test (e.g., where reproduction and growth of confined populations are observed) and/or an actual field test (e.g., where reproduction and growth of natural populations are observed) are required if laboratory data indicate adverse long-term, cumulative, or life-cycle effects may result from intended use. [49 FR 42881, Oct. 24, 1984. Redesignated at 53 FR 15993, May 4, 1988, and amended at 58 FR 34203, June 23, 1993] [[Page 133]] Appendix A to Part 158--Data Requirements for Registration: Use Pattern Index How to use this Index: 1. Identify the Pesticide Use Site Group listed below (e.g., agricultural crops, forests, ornamental plants) that covers the specific use pattern of interest to you. 2. Find your specific use pattern under the appropriate Pesticide Use Site Group. 3. Identify the general use pattern that corresponds to your specific use pattern. 4. Use the general use pattern in determining applicable data requirements on the Data Requirements tables presented in Sec. Sec. 158.120 through 153.170. Pesticide use site group 1. Agricultural Crops. 2. Ornamental Plants and Forest Trees. 3. General Soil Treatment and Composting. 4. Processed or Manufactured Products, and food or feed containers or dispensers. 5. Pets and Domestic Animals. 6. Agricultural Premises and Equipment. 7. Household. 8. Wood or Wood Structure Protection Treatments. 9. Aquatic sites. 10. Noncrop, wide area, and general indoor/outdoor treatments. 11. Antifouling treatments. 12. Commercial and Industrial Uses. 13. Domestic and Human Use. 14. Miscellaneous Indoor Uses. ------------------------------------------------------------------------ Specific use patterns--listed according to Corresponding general use use site group pattern ------------------------------------------------------------------------ 1. Agricultural crops Small fruits Terrestrial food crop Caneberries (e.g., raspberry, dewberry) Bushberries (e.g., blueberry, currant) Vine fruits (e.g., grape, kiwi fruit) Strawberry Cranberry Pome fruits (e.g., apple, quince) Stone fruits (e.g., peach, cherry) Nut crops--tree & shrub (e.g., pecan, filbert) Other temperate fruits (e.g., persimmon, pawpaw) Tropical and subtropical fruits Citrus Banana and plantain Palm fruits and nuts (e.g., date, coconut) Pineapple Other fruits and nuts Beverage crops Woody--cocoa, coffee, tea Herbaceous--chicory, mint Flavoring and spice crops Woody--leaf/stem, root, seed and pod Herbac.--leaf/stem, root, seed and pod Vegetables--leaf/stem, root, seed and pod, fruiting vegetables, cucurbits Commercial annual (e.g., tomato, bean) Commercial perennial (e.g., asparagus, rhubarb) Greenhouse (commercial) Greenhouse food crop Mushrooms Nursery/seed crop/medical crop/tobacco Greenhouse non-food crop Fiber crops Terrestrial food crop Cotton Others--(e.g., flax) Forage crops Typical grasses--annual (e.g., sudan grass) Typical grasses--perennial (e.g., bromegrass) Corn and sorghum Small grains for forage (e.g., rye) Perennial legumes (e.g., white clover) Annual legumes (e.g., crotalaria, soybean) Crop harvest residue (peanut vines, beet tops, etc.) Grain and edible seed crops Corn Rice Aquatic food crop Wheat, barley, rye, oats Terrestrial food crop Sorghum Alfalfa Other grains Other nongrains (e.g., squash, pumpkin) Buckwheat Sesame Peanut Sunflower Seed sprout crops Mung bean, red clover, soybean, alfalfa, etc. Nonlegume crops (e.g., wheat, radish, black mustard) Crops grown exclusively for seed for planting Sugar crops Stored raw agricultural commodities Indoor Honey (principal nectar-producing crops) Sugar beet Sugarcane Sugar maple Sorghum (for sugar) Crops for smoking and chewing Terrestrial nonfood crop --field --shade --storage --greenhouses Sapodilla (for chewing gum) Terrestrial food crop Oil crops Annual herbaceous crops Perennial herbaceous crops Tropical/subtropical woody crops Drug and medicinal crops Terrestrial nonfood crop Annual herbaceous crops Perennial herbaceous crops Temperate woody crops Tropical/subtropical wood crops [[Page 134]] 2. Ornamental plants and forest trees Ornamental plants Terrestrial nonfood crop Annual garden plants Temperate perennial nonfood garden herbs Commercial greenhouse crops Greenhouse nonfood crop Houseplants Indoor Home and retail greenhouse and conservatory plants Public display plantings Terrestrial nonfood crop Bulb, corm, and tuber ornamentals Subtropical/tropical garden evergreen plants (dry--e.g., agave) Subtropical/tropical garden evergreen plants (moist--e.g., ferns) Groundcovers Aquatic plants (e.g., waterlilies) Aquatic nonfood use Ornamental trees, shrubs, and vines (woody) Terrestrial nonfood crop Deciduous temperate broadleaf Evergreen temperate broadleaf Deciduous temperate conifer Evergreen temperate conifer Tropical/subtropical broadleaf Tropical/subtropical conifer Tropical/subtropical miscellaneous (e.g., cycad, tree fern, bamboo) Lawn and turf grasses--ornamental Terrestrial nonfood crop or domestic outdoor Cool season Winter grasses (bent, bluegrass, fescue, etc.) Summer grasses (zoysia, bermudagrass, etc.) Ornamental bunch grasses (pampasgrass, blue fescue) Forest trees--nonornamental--trees forests, Forestry plantings Deciduous temperate (broadleaf) Evergreen temperate (broadleaf) Deciduous and evergreen conifers Tropical/subtropical broadleaf Tropical/subtropical conifer Forest tree nurseries--Temperate broadleaf trees Temperate conifer trees Forest trees: dead trees/logs/stumps in the forest or in plantings 3. General soil treatment and composting General soil treatments Terrestrial nonfood crop Soil application with no mention of crops to be grown (potting soil, top soil). Manure Composts Cull piles Mulches 4. Processed or manufactured products, and food or feed containers or dispensers Processed vegetables, fruits, and nuts Indoor Fruits Leafy vegetables Root vegetables Fruited vegetables Nuts Peanuts Seeds (sesame, sunflower) Dried processed Fruits Vegetables Tobacco Beverages (tea, coffee) Herbs and spices Animal Feeds Cattle (beef) Cattle (dairy) Goat (nondairy) Goat (dairy) Horse, mule, donkey Poultry (chicken, turkey, etc.) Sheep (meat) Sheep (wool) Swine Dog Cat Other pets (including birds) Fur-bearing stock Other meat-producing stock (e.g., rabbit) Fish food (commercial) Fish food (pet) Birdseed Processed grain products for human consumption Corn Soybean Wheat Other grains (rice, barley, etc.) Cereal foods Flour Baked goods Farinaceous products Processed animal products for human consumption Cheese Egg yolks Meats, including fish and poultry Milk Processed plant products for human consumption Chocolate Candy Sugar Yeast Citrus pulp Chewing gum Cigarettes, etc. Herbs and spices Pickles Glazed fruits Jellies Seed oils Fruit syrups (e.g., cola) Fruit juices Fermentation beverages (wine, beer, whiskey, vinegar) Processed or manufactured nonfood plant and animal products Textiles, fabrics, fibers Fur and hair products Leather products Food and feed containers, dispensers, and processing equipment Airtight storages--large (empty/full) Airtight storages--small (empty/full) Fumigation chambers Bins Elevators [[Page 135]] Storage areas--(empty/full) Processing or handling equipment and machinery (other than food processing) 5. Pets and domestic animals--animals and their man-made premises Dairy cattle--lactating Indoor Dairy cattle--nonlactating Dairy cattle--heifers, calves Goats--lactating Goats--nonlactating Goats--young (kids) Fur- and wool-bearing animals Goats Sheep Mink Chinchilla Rabbit Fox Nutria Meat animals (mammals) Cattle (and calves) Goats (and kids) Horses Rabbits Sheep (and lambs) Swine Bison Reindeer Poultry (meat, eggs) Chickens Turkeys Ducks, geese Guineas, pheasants, quail, etc. Honey production Bees Beehives Honeycombs Fish and shellfish production Aquatic food use Hatchery buildings Culture ponds, containers Animals for labor, display, riding, racing, Indoor lab use, etc. Dogs Horses, donkeys, mules Guinea pigs Mice Rats Gerbils Hamsters Monkeys Cats Chickens, birds Wild rodents Alfalfa leafcutting bee (pollinator) Alkaline bee (pollinator) Zoo ruminants Zoo ungulates Zoo canines Zoo felines Zoo primates Zoo reptiles Zoo amphibians Zoo birds Zoo--others Aquarium fish Animals for pets, including their cages, bedding, nests, etc. Dogs Cats Birds Rodents Lagomorphs Fish Amphibians Reptiles Primates Other vertebrates 6. Agricultural premises and equipment Egg handling facilities and equipment Indoor Egg washers Egg rooms Hatching egg treatments Hatching egg rooms Hatching egg equipment Egg packing plants and hatcheries Milk handling facilities and equipment Milk storage rooms Milking stalls and parlors Milking machines, milk tanks, etc. Teat cups, liners, etc. Milk processing equipment 7. Household Non-food area and sites Indoor Closets, storage areas Basements, cellars Bedrooms Attics Recreation rooms Living rooms Baseboards, window sills, etc. Plumbing fixtures Sickrooms Food-handling and food storage areas Kitchens Dining rooms Pantry and food storage shelving Household contents and space Air Beds Rugs Book cases Furs, fabrics, blankets Play pens Sickroom utensils Filters for air vents, air conditioners, furnaces, etc. Outdoor areas (Noncommercial homeowner use) Domestic outdoor or terrestrial food crop Home garden, orchards Porches Domestic outdoor Patios Foundations Steps Eaves Yards, lawn, turf Domestic ornamental plantings 8. Wood or Wood Structure Protection Treatments Buildings (for termite, powderdust beetle Domestic outdoor or indoor controls, etc.) Unseasoned forest products Seasoned forest products Finished wood products Wood pressure treatments Plant-growing wood structures and containers Wood containers for nonfood, nonfeed uses 9. Aquatic sites Food processing water systems Aquatic food crop Poultry and livestock drinking water Pulp and papermill systems Aquatic noncrop Swimming pool water Industrial disposal systems [[Page 136]] Industrial ponds Human drinking water Aquatic food crop Cooling water towers Aquatic noncrop Agricultural irrigation water, and ditches Aquatic food crop Agricultural drainage water and ditches Sewage systems and drainfields Aquatic noncrop Dishwashing water Indoor Domestic and commercial nonpotable water Aquatic noncrop Lakes, ponds, impounded water Streams, rivers, canals Swamps, marshes, wetlands Air conditioner water Humidifier water Air washer water systems Secondary oil recovery injection water Heat exchange water system Polluted water Bait boards (floating--for vertebrate control) Catch basins, puddles, tree holes Estuaries, tidal marshes Commercial and sport fish-bearing waters Aquatic food crop 10. Noncrop, wide area, and general indoor/ outdoor treatments Uncultivated agricultural areas (nonfood Terrestrial noncrop producing) Farmyards Fuel storage areas Fence rows Rights-of-way Fallow land Terrestrial food crop Soil bank land Terrestrial noncrop Barrier strips Uncultivated nonagricultural areas (outdoor) Airports Recreation areas, fairgrounds, race tracks, tennis courts, etc. Campgrounds Recreation area structures Highway rights-of-way Railroad rights-of-way Utility rights-of-way Sewage disposal areas Industrial sites (lumberyards, tank farms, etc.) Paved areas Private roads and walks Fencerows and hedgerows (nonagricultural) Directed Pest Control to Pests' Nests, etc., Terrestrial noncrop or and for Traps indoor Diseased beehives Nuisance bee nests Ant mounds, hills, dens Termite mounds Insect traps (chemical lures) Repellents and irritants to pests (when not covered by other sites) Wide area and general indoor/outdoor treatments Rural areas (unspecified) Urban areas (unspecified) Public buildings and structures Animal burrow entrances, dens, tunnels Animal nests Animal trails Mammal feeding areas Nonagricultural areas for public health treatments Bird roosting, nesting areas Bird feeding areas 11. Antifouling Treatments Sites for marine exposures Aquatic noncrop Boat bottoms and other submersed structures Steel Fiberglass Aluminum Wood Plastic Other substances and materials Crab pots and lobster pots Sites for fresh water exposures Cooling tower influent conduits 12. Commercial and Industrial Uses Transportation Facilities Indoor Bus Truck and Trailer Containerized units Railroad cars Aircraft Ships/barges Auto, taxis Recreational vehicles Shipping containers Food and feed processing plants Bakeries Bottlers Canneries Dairies, creameries, milk processing plants Feed mills, feed stores Fresh fruit packing and processing Meat processing Poultry processing Wineries, wine cellars Flour mills, machinery, warehouses, bins, elevators Egg processing Candy and confectionary plants Sugar processing, cane mills, etc. Cider mills Dry food products plants Tobacco processing Air treatment for processing and transportation of foods Beverage processing Nut processing Cereal processing Seafood processing Vegetable oil processing Spice mills Vinegar processing Farinaceous processing (noodles, etc.) Mushroom processing Dried fruit processing Pickle processing Ice plants Chocolate processing Fruit juice processing Eating establishments (all) Food handling areas Food serving areas Eating establishment nonfood areas Air treatment for eating establishments Food storage equipment (coolers, refrigerators, etc.) [[Page 137]] Eating and serving utensils (spoons, etc.) Food marketing, storage, and distribution Food dispensing and vending equipment Food stores, markets, stands Meat and fish markets Food catering facilities Food marketing, storage, and distribution equipment and utensils Hospitals and related institutions and facilities Critical premises (e.g., burn wards, etc.) Hospital patient premises (wards, emergency rooms, etc.) Noncritical premises (labs, lounges, lobbies, storage) Critical items (hypodermic needles, dental instruments, catheters, etc.) Noncritical items (bedpans, carpets, furniture, etc.) Air treatment (also to ambulances) Janitorial equipment Barber and beauty shop instruments and equipment Morgues, mortuaries, and funeral homes Premises (embalming rooms, etc.) Equipment (tables, etc.) Instruments Burial vaults, mausoleums Air treatment Commercial, institutional, and industrial Maintenance, Buildings, and Structures Locker rooms, equipment Gyms, bowling alleys, and equipment Telephones and booths Shower rooms, mats, and equipment Cotton mill premises and equipment Auditoriums and stadiums Factories Rendering plants Loading areas, ramps School buildings and equipment Office buildings Laundries Fuels from Crops (alcohol, methane) Fossil fuels (e.g., oils, jet fuel) Seed oils Paper Pesticide materials preservation and protection Rodenticide baits (protection against insects) Dried plant parts (pyrethrum, red squill, rotenone, sabadilla) Paints Preservatives and protectants Grains Hay, silage Adhesives Coatings (asphalt and lacquer) Fuels Leather and leather products Leather processing liquors Metalworking cutting fluids Oil recovery drilling muds and packer fluids Paints (latex) Paper and paper products Plastic products Resin emulsions Rubber (natural) products Specialty products (polishes, cleansers, dyes, etc.) Textiles, textile fibers, and cordage Wet-end additives, etc. (pulp sizing, alum, casein, printing pastes) Disposable diapers Wool, hair, mohair, furs, felt, feathers, etc. Electrical supplies, cables, and equipment 13. Domestic and Human Use Human Body and Hair Indoor Fiber product protection (Moth, mildew-proofing) Clothing Upholstery Ornamental fabrics (draperies, tapestries) Ropes Sail cloth Human articles and materials Bedding, blankets, mattresses (Treatments to) hair, body, clothing (while being worn) Clothing Face gear (goggles, face masks, etc.) Headgear (safety helmets, headphones, etc.) Wigs Contact lenses Dentures, toothbrushes, mouthpieces to musical instruments, etc. Brick, asbestos, etc. Wood surfaces Leather surfaces Fabric surfaces Paper/paperboard surfaces Specialty uses Museum collectors (preserved animal and plant specimens) Military uses--not specified Quarantine uses--not specified DHHS/FDA uses--not specified Filters (air conditioning, air, and furnace) Biological specimens Underground cables Cuspidors, spittoons Vomitus Human wastes Air sanitizers Diapers Laundry equipment (carts, chutes, tables, etc.) Dust control--products and equipment (mops, etc.) Dry cleaning Carpets Upholstery Bathrooms, toilets bowls, and related sites Bathroom premises Toilet bowls and urinals Toilet tanks Portable toilets, chemical toilets [[Page 138]] Vehicular holding tanks Bathroom air treatment Diaper pails Refuse and soild waste Refuse and solid waste containers Refuse and solid waste transportation and handling equipment Garbage dumps Household trash compactors Garbage disposal units, food disposals Incinerators 14. Miscellaneous Indoor Uses Surface Treatments Indoor Hard nonporous surfaces (painted, tile, plastic, metal, glass, etc.) Hard porous surfaces (cement, plaster) Camping equipment and gear Grooming instruments (brushes, clippers, razors, etc.) Laundry, cleaning, and dry cleaning ------------------------------------------------------------------------