[Code of Federal Regulations] [Title 21, Volume 2] [Revised as of April 1, 2008] From the U.S. Government Printing Office via GPO Access [CITE: 21CFR111.60] [Page 237] TITLE 21--FOOD AND DRUGS CHAPTER I--FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) PART 111_CURRENT GOOD MANUFACTURING PRACTICE IN MANUFACTURING, PACKAGING, LABELING, OR HOLDING OPERATIONS FOR DIETARY SUPPLEMENTS--Table of Contents Subpart E_Requirement to Establish a Production and Process Control System Sec. 111.60 What are the design requirements for the production and process control system? (a) Your production and in-process control system must be designed to ensure that the dietary supplement is manufactured, packaged, labeled, and held in a manner that will ensure the quality of the dietary supplement and that the dietary supplement is packaged and labeled as specified in the master manufacturing record; and (b) The production and in-process control system must include all requirements of subparts E through L of this part and must be reviewed and approved by quality control personnel.