[Code of Federal Regulations] [Title 21, Volume 5] [Revised as of April 1, 2008] From the U.S. Government Printing Office via GPO Access [CITE: 21CFR349.70] [Page 286] TITLE 21--FOOD AND DRUGS CHAPTER I--FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF PART 349_OPHTHALMIC DRUG PRODUCTS FOR OVER-THE-COUNTER HUMAN USE--Table of Contents Subpart C_Labeling Sec. 349.70 Labeling of ophthalmic hypertonicity drug products. (a) Statement of identity. The labeling of the product contains the established name of the drug, if any, and identifies the product as a ``hypertonicity'' (select one of the following: ``eye'' or ``ophthalmic'') ``(insert dosage form, e.g., drops).'' (b) Indications. The labeling of the product states, under the heading ``Indications,'' the following phrase: ``For the temporary relief of corneal edema.'' (c) Warnings. In addition to the warnings in Sec. 349.50, the labeling of the product contains the following warnings under the heading ``Warnings'' for products containing any ingredient identified in Sec. 349.16: (1) ``Do not use this product except under the advice and supervision of a doctor. If you experience eye pain, changes in vision, continued redness or irritation of the eye, or if the condition worsens or persists, consult a doctor.'' (2) ``This product may cause temporary burning and irritation on being instilled into the eye.'' (3) ``If solution changes color or becomes cloudy, do not use.'' (d) Directions. The labeling of the product contains the following information under the heading ``Directions'': Instill 1 or 2 drops in the affected eye(s) every 3 or 4 hours, or as directed by a doctor.