[Code of Federal Regulations] [Title 21, Volume 8] [Revised as of April 1, 2008] From the U.S. Government Printing Office via GPO Access [CITE: 21CFR814.108] [Page 142] TITLE 21--FOOD AND DRUGS CHAPTER I--FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) PART 814_PREMARKET APPROVAL OF MEDICAL DEVICES--Table of Contents Subpart H_Humanitarian Use Devices Sec. 814.108 Supplemental applications. After FDA approval of an original HDE, an applicant shall submit supplements in accordance with the requirements for PMA's under Sec. 814.39, except that a request for a new indication for use of a HUD shall comply with requirements set forth in Sec. 814.110. The timeframes for review of, and FDA action on, an HDE supplement are the same as those provided in Sec. 814.114 for an HDE. [63 FR 59220, Nov. 3, 1998]